Host-directed therapies for infectious diseases: current status, recent progress, and future prospects

Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage. The continuing epidemics of tuberculosis, HIV, malaria, and influenza, and the emerg...

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Published inThe Lancet infectious diseases Vol. 16; no. 4; pp. e47 - e63
Main Authors Zumla, Alimuddin, Rao, Martin, Wallis, Robert S, Kaufmann, Stefan H E, Rustomjee, Roxana, Mwaba, Peter, Vilaplana, Cris, Yeboah-Manu, Dorothy, Chakaya, Jeremiah, Ippolito, Giuseppe, Azhar, Esam, Hoelscher, Michael, Maeurer, Markus
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.04.2016
Elsevier Limited
Subjects
Antibodies, Monoclonal - therapeutic use
Bone marrow
Cell- and Tissue-Based Therapy - methods
Communicable Diseases - immunology
Communicable Diseases - therapy
Cytokines - therapeutic use
Drug Resistance
Host-Pathogen Interactions - immunology
Humans
Infectious Disease
Infectious diseases
Kinases
Lymphocytes
Malaria
Mortality
Pathogens
Public health
Tuberculosis
Tumor necrosis factor-TNF
Vector-borne diseases
Vitamins - therapeutic use
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Abstract Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage. The continuing epidemics of tuberculosis, HIV, malaria, and influenza, and the emergence of novel zoonotic pathogens represent major clinical management challenges worldwide. Newer approaches to improving treatment outcomes are needed to reduce the high morbidity and mortality caused by infectious diseases. Recent insights into pathogen–host interactions, pathogenesis, inflammatory pathways, and the host's innate and acquired immune responses are leading to identification and development of a wide range of host-directed therapies with different mechanisms of action. Host-directed therapeutic strategies are now becoming viable adjuncts to standard antimicrobial treatment. Host-directed therapies include commonly used drugs for non-communicable diseases with good safety profiles, immunomodulatory agents, biologics (eg monoclonal antibodies), nutritional products, and cellular therapy using the patient's own immune or bone marrow mesenchymal stromal cells. We discuss clinically relevant examples of progress in identifying host-directed therapies as adjunct treatment options for bacterial, viral, and parasitic infectious diseases.
AbstractList Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage. The continuing epidemics of tuberculosis, HIV, malaria, and influenza, and the emergence of novel zoonotic pathogens represent major clinical management challenges worldwide. Newer approaches to improving treatment outcomes are needed to reduce the high morbidity and mortality caused by infectious diseases. Recent insights into pathogen–host interactions, pathogenesis, inflammatory pathways, and the host's innate and acquired immune responses are leading to identification and development of a wide range of host-directed therapies with different mechanisms of action. Host-directed therapeutic strategies are now becoming viable adjuncts to standard antimicrobial treatment. Host-directed therapies include commonly used drugs for non-communicable diseases with good safety profiles, immunomodulatory agents, biologics (eg monoclonal antibodies), nutritional products, and cellular therapy using the patient's own immune or bone marrow mesenchymal stromal cells. We discuss clinically relevant examples of progress in identifying host-directed therapies as adjunct treatment options for bacterial, viral, and parasitic infectious diseases.
Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage. The continuing epidemics of tuberculosis, HIV, malaria, and influenza, and the emergence of novel zoonotic pathogens represent major clinical management challenges worldwide. Newer approaches to improving treatment outcomes are needed to reduce the high morbidity and mortality caused by infectious diseases. Recent insights into pathogen-host interactions, pathogenesis, inflammatory pathways, and the host's innate and acquired immune responses are leading to identification and development of a wide range of host-directed therapies with different mechanisms of action. Host-directed therapeutic strategies are now becoming viable adjuncts to standard antimicrobial treatment. Host-directed therapies include commonly used drugs for non-communicable diseases with good safety profiles, immunomodulatory agents, biologics (eg monoclonal antibodies), nutritional products, and cellular therapy using the patient's own immune or bone marrow mesenchymal stromal cells. We discuss clinically relevant examples of progress in identifying host-directed therapies as adjunct treatment options for bacterial, viral, and parasitic infectious diseases.Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage. The continuing epidemics of tuberculosis, HIV, malaria, and influenza, and the emergence of novel zoonotic pathogens represent major clinical management challenges worldwide. Newer approaches to improving treatment outcomes are needed to reduce the high morbidity and mortality caused by infectious diseases. Recent insights into pathogen-host interactions, pathogenesis, inflammatory pathways, and the host's innate and acquired immune responses are leading to identification and development of a wide range of host-directed therapies with different mechanisms of action. Host-directed therapeutic strategies are now becoming viable adjuncts to standard antimicrobial treatment. Host-directed therapies include commonly used drugs for non-communicable diseases with good safety profiles, immunomodulatory agents, biologics (eg monoclonal antibodies), nutritional products, and cellular therapy using the patient's own immune or bone marrow mesenchymal stromal cells. We discuss clinically relevant examples of progress in identifying host-directed therapies as adjunct treatment options for bacterial, viral, and parasitic infectious diseases.
Summary Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage. The continuing epidemics of tuberculosis, HIV, malaria, and influenza, and the emergence of novel zoonotic pathogens represent major clinical management challenges worldwide. Newer approaches to improving treatment outcomes are needed to reduce the high morbidity and mortality caused by infectious diseases. Recent insights into pathogen–host interactions, pathogenesis, inflammatory pathways, and the host's innate and acquired immune responses are leading to identification and development of a wide range of host-directed therapies with different mechanisms of action. Host-directed therapeutic strategies are now becoming viable adjuncts to standard antimicrobial treatment. Host-directed therapies include commonly used drugs for non-communicable diseases with good safety profiles, immunomodulatory agents, biologics (eg monoclonal antibodies), nutritional products, and cellular therapy using the patient's own immune or bone marrow mesenchymal stromal cells. We discuss clinically relevant examples of progress in identifying host-directed therapies as adjunct treatment options for bacterial, viral, and parasitic infectious diseases.
Author Rao, Martin
Yeboah-Manu, Dorothy
Ippolito, Giuseppe
Chakaya, Jeremiah
Rustomjee, Roxana
Vilaplana, Cris
Zumla, Alimuddin
Hoelscher, Michael
Mwaba, Peter
Kaufmann, Stefan H E
Wallis, Robert S
Maeurer, Markus
Azhar, Esam
Author_xml – sequence: 1
  givenname: Alimuddin
  surname: Zumla
  fullname: Zumla, Alimuddin
  organization: Centre for Clinical Microbiology, Division of Infection and Immunity, University College London (UCL), London, UK
– sequence: 2
  givenname: Martin
  surname: Rao
  fullname: Rao, Martin
  organization: Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
– sequence: 3
  givenname: Robert S
  surname: Wallis
  fullname: Wallis, Robert S
  organization: Aurum Institute, Johannesburg, South Africa
– sequence: 4
  givenname: Stefan H E
  surname: Kaufmann
  fullname: Kaufmann, Stefan H E
  organization: Max Planck Institute for Infection Biology, Berlin, Germany
– sequence: 5
  givenname: Roxana
  surname: Rustomjee
  fullname: Rustomjee, Roxana
  organization: South African Medical Research Council, Cape Town, South Africa
– sequence: 6
  givenname: Peter
  surname: Mwaba
  fullname: Mwaba, Peter
  organization: University of Zambia-UCL Medical School (UNZA-UCLMS) Research and Training Project, University Teaching Hospital, Lusaka, Zambia
– sequence: 7
  givenname: Cris
  surname: Vilaplana
  fullname: Vilaplana, Cris
  organization: Unitat de Tuberculosi Experimental Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol CIBER Enfermedades Respiratorias, Can Ruti Campus, Edifici Laboratoris de Recerca, Barcelona, Spain
– sequence: 8
  givenname: Dorothy
  surname: Yeboah-Manu
  fullname: Yeboah-Manu, Dorothy
  organization: Bacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
– sequence: 9
  givenname: Jeremiah
  surname: Chakaya
  fullname: Chakaya, Jeremiah
  organization: Kenya Medical Research Institute, Nairobi, Kenya
– sequence: 10
  givenname: Giuseppe
  surname: Ippolito
  fullname: Ippolito, Giuseppe
  organization: National Institute for Infectious Diseases, Lazzaro Spallanzani, Rome, Italy
– sequence: 11
  givenname: Esam
  surname: Azhar
  fullname: Azhar, Esam
  organization: Special Infectious Agents Unit, King Fahd Medical Research Centre, and Medical Laboratory Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
– sequence: 12
  givenname: Michael
  surname: Hoelscher
  fullname: Hoelscher, Michael
  organization: Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich, Munich, Germany
– sequence: 13
  givenname: Markus
  surname: Maeurer
  fullname: Maeurer, Markus
  email: markus.maeurer@ki.se
  organization: Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27036359$$D View this record in MEDLINE/PubMed
http://kipublications.ki.se/Default.aspx?queryparsed=id:133213366$$DView record from Swedish Publication Index
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Koussounda, F K
Bjune, G
Gagneux, Sebastien
Macete, Eusebio
Dieye, A
Cardona, Pierre
Mbow, M
Aseffa, Abraham
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Mfinanga, Elirehema
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Mayosi, Bongani
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Sanne, Ian
Edwards, Sarah
Menendez, C
Parida, Shreemanta
Toure, M O
Steyn, Andrie
Chaula, Zainab
Churchyard, Gavin
Fortune, Farida
Mfinanga, Sayoki
Schito, Marco
Kibaki, Gibson
Antonio, Martin
Andersen, Peter Lawætz
Gyapong, J
Padayachin, Nesri
Wilkinson, Robert
Loots, Glaudina
Mboko, Leonard
Kaleebu, Pontiano
Aklilu, Eleni
Oukem, O
Kiepiela, Photini
Volmink, Jimmy
Bonnet, Maryline
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Copyright 2016 Elsevier Ltd
Elsevier Ltd
Copyright © 2016 Elsevier Ltd. All rights reserved.
Copyright Elsevier Limited Apr 2016
Copyright © 2016 Elsevier Ltd. All rights reserved. 2016 Elsevier Ltd
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Snippet Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of...
Summary Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important...
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SubjectTerms Antibodies, Monoclonal - therapeutic use
Bone marrow
Cell- and Tissue-Based Therapy - methods
Communicable Diseases - immunology
Communicable Diseases - therapy
Cytokines - therapeutic use
Drug Resistance
Host-Pathogen Interactions - immunology
Humans
Infectious Disease
Infectious diseases
Kinases
Lymphocytes
Malaria
Mortality
Pathogens
Public health
Tuberculosis
Tumor necrosis factor-TNF
Vector-borne diseases
Vitamins - therapeutic use
Title Host-directed therapies for infectious diseases: current status, recent progress, and future prospects
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https://www.clinicalkey.es/playcontent/1-s2.0-S1473309916000785
https://dx.doi.org/10.1016/S1473-3099(16)00078-5
https://www.ncbi.nlm.nih.gov/pubmed/27036359
https://www.proquest.com/docview/1776426355
https://www.proquest.com/docview/1777983420
https://pubmed.ncbi.nlm.nih.gov/PMC7164794
http://kipublications.ki.se/Default.aspx?queryparsed=id:133213366
Volume 16
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