GLP-1R Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes After Experimental Myocardial Infarction in Mice

• Published in: Diabetes (New York, N.Y.) Vol. 58; no. 4; pp. 975 - 983
• Main Authors: Noyan-Ashraf, Mohammad Hossein, Momen, M. Abdul, Ban, Kiwon, Sadi, Al-Muktafi, Zhou, Yu-Qing, Riazi, Ali M., Baggio, Laurie L., Henkelman, R. Mark, Husain, Mansoor, Drucker, Daniel J.
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.04.2009
• Subjects: Animals; Biological and medical sciences; Blood Glucose - metabolism; Body Weight; Cardiac function; Cardiology. Vascular system; Cardiomegaly - pathology; Cardiomyocytes; Cellular signal transduction; Coronary heart disease; Coronary vessels; Diabetes; Diabetes Mellitus, Type 2 - drug therapy; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - drug therapy; Diet; Disease Models, Animal; Dosage and administration; Drug therapy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Glucagon; Glucagon-Like Peptide 1 - analogs & derivatives; Glucagon-Like Peptide 1 - therapeutic use; Glucagon-Like Peptide-1 Receptor; Heart; Heart - anatomy & histology; Heart attack; Heart attacks; Heart failure; Human subjects; Humans; Hypoglycemic agents; Ischemia; Liraglutide; Male; Medical sciences; Mice; Mice, Inbred C57BL; Myocardial Infarction - drug therapy; Myocarditis. Cardiomyopathies; Organ Size; Original; Peptides; Receptors, Glucagon - agonists; Research design; Survival analysis; Type 2 diabetes; Veins & arteries; Canada; Endocrinopathy; Myocardial infarction; Vertebrata; Agonist; Mammalia; Mouse; Animal; Diabetes mellitus; Rodentia; Cardiovascular disease; Coronary heart disease; Myocardial disease

GLP-1R Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes After Experimental Myocardial Infarction in Mice Mohammad Hossein Noyan-Ashraf 1 , M. Abdul Momen 1 , Kiwon Ban 1 , 6 , Al-Muktafi Sadi 1 , Yu-Qing Zhou 2 , Ali M. Riazi 2 , Laurie L. Baggio 3 , R. Mark Henkelman 2 ,...