Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 59; no. 1; pp. 33 - 42
• Main Authors: Hwang, Hyonson, Bowen, Benjamin P., Lefort, Natalie, Flynn, Charles R., De Filippis, Elena A., Roberts, Christine, Smoke, Christopher C., Meyer, Christian, Højlund, Kurt, Yi, Zhengping, Mandarino, Lawrence J.
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.01.2010
• Subjects: Adult; Analysis; Biological and medical sciences; Biopsy; Body Mass Index; Chaperonin Containing TCP-1 - genetics; Chaperonins - genetics; Cytoskeletal Proteins - genetics; Diabetes; Diabetes Mellitus, Type 2 - genetics; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Profiling; Glucose Clamp Technique; Health aspects; Humans; Hypotheses; Insulin resistance; Male; Mass Spectrometry; Medical sciences; Metabolic diseases; Metabolism; Middle Aged; Mitochondria, Muscle - metabolism; Muscle, Skeletal - physiopathology; Muscles; Musculoskeletal system; Obesity; Obesity - genetics; Original; Pathogenesis; Peptide Hydrolases - genetics; Physiological aspects; Proteins; Proteomics; Proteomics - methods; Reference Values; Reproducibility; Research design; Scientific imaging; Skeletal muscle; Striated muscle. Tendons; Type 2 diabetes; Vertebrates: osteoarticular system, musculoskeletal system; Endocrinopathy; Type 2 diabetes; Human; Obesity; Nutrition disorder; Metabolic diseases; Striated muscle; Nutritional status

Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes Hyonson Hwang 1 , 2 , Benjamin P. Bowen 1 , 3 , Natalie Lefort 1 , 2 , Charles R. Flynn 1 , Elena A. De Filippis 1 , Christine Roberts 1 , Christopher C. Smoke 1 , Christian Meyer 1 , Kurt Højlund...