Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons

• Published in: Nature communications Vol. 9; no. 1; pp. 5124 - 7
• Main Authors: Vågerö, Denny, Pinger, Pia R., Aronsson, Vanda, van den Berg, Gerard J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.12.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 692/499; 692/700/2814; 692/700/478/174; 706/689; Aged; Animals; Cancer; Cardiovascular diseases; Cardiovascular Diseases - mortality; Cardiovascular Diseases - physiopathology; Child; Children; Cohort Studies; Datasets; Diabetes mellitus; Diabetes Mellitus - mortality; Diabetes Mellitus - physiopathology; Family; Female; Food; Grandparents; Humanities and Social Sciences; Humans; Male; Males; Middle Aged; Mortality; multidisciplinary; Neoplasms - mortality; Neoplasms - physiopathology; Nutrition Assessment; Nutritional Status; Pedigree; Plant nutrition; Puberty; Science; Sweden; Sweden
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-018-07617-9

Studies of animals and plants suggest that nutritional conditions in one generation may affect phenotypic characteristics in subsequent generations. A small number of human studies claim to show that pre-pubertal nutritional experience trigger a sex-specific transgenerational response along the male line. A single historical dataset, the Överkalix cohorts in northern Sweden, is often quoted as evidence. To test this hypothesis on an almost 40 times larger dataset we collect harvest data during the pre-pubertal period of grandparents (G0, n = 9,039) to examine its potential association with mortality in children (G1, n = 7,280) and grandchildren (G2, n = 11,561) in the Uppsala Multigeneration Study. We find support for the main Överkalix finding: paternal grandfather’s food access in pre-puberty predicts his male, but not female, grandchildren’s all-cause mortality. In our study, cancer mortality contributes strongly to this pattern. We are unable to reproduce previous results for diabetes and cardiovascular mortality. Nutritional experience can have phenotypic consequences in subsequent generations, as is evident from studies in animals and plants. Here, Vågerö et al. find in a large three-generation cohort that access to food in the paternal grandfather associates with all-cause and cancer mortality in male grandchildren.