Abnormal Left and Right Amygdala-Orbitofrontal Cortical Functional Connectivity to Emotional Faces: State Versus Trait Vulnerability Markers of Depression in Bipolar Disorder

• Published in: Biological psychiatry (1969) Vol. 67; no. 5; pp. 422 - 431
• Main Authors: Versace, Amelia, Thompson, Wesley K., Zhou, Donli, Almeida, Jorge R.C., Hassel, Stefanie, Klein, Crystal R., Kupfer, David J., Phillips, Mary L.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2010; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Affect; Amygdala; Amygdala - physiopathology; Anisotropy; Biological and medical sciences; bipolar disorder; Bipolar Disorder - diagnosis; Bipolar Disorder - physiopathology; Bipolar Disorder - psychology; Bipolar disorders; Depression; Depressive Disorder, Major - diagnosis; Depressive Disorder, Major - physiopathology; Depressive Disorder, Major - psychology; Diagnosis, Differential; Diagnostic and Statistical Manual of Mental Disorders; emotional processing; Face; Facial Expression; Female; functional connectivity; Functional Laterality - physiology; Humans; Magnetic Resonance Imaging; Male; Medical sciences; Mood disorders; Nerve Net - physiopathology; neuroimaging; OFC; Prefrontal Cortex - physiopathology; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Surveys and Questionnaires; bipolar disorder; functional connectivity; Amygdala; OFC; emotional processing; neuroimaging; Mood disorder; Affect affectivity; Orbitofrontal cortex; Central nervous system; Depression; Bipolar disorder; Cognition; Basal ganglion; Emotion emotionality; Vulnerability; Encephalon; Information processing; Face; Amygdaloid nucleus; Comparative study; Facial expression

Amygdala-orbitofrontal cortical (OFC) functional connectivity (FC) to emotional stimuli and relationships with white matter remain little examined in bipolar disorder individuals (BD). Thirty-one BD (type I; n = 17 remitted; n = 14 depressed) and 24 age- and gender-ratio-matched healthy individuals...