Determination of the half-life of circulating leptin in the mouse

• Published in: International Journal of Obesity Vol. 41; no. 3; pp. 355 - 359
• Main Authors: Burnett, L C, Skowronski, A A, Rausch, R, LeDuc, C A, Leibel, R L
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2017; Nature Publishing Group
• Subjects: 631/443/319/1642/393; 631/45/776/1178; 692/53; Adipocytes; Animals; Body fat; Body weight; Cell metabolism; Development and progression; Enzyme-linked immunosorbent assay; Epidemiology; Glucose; Half-life; Health aspects; Health Promotion and Disease Prevention; Homeostasis; Human subjects; Insulin; Internal Medicine; Laboratories; Leptin; Medicine; Medicine & Public Health; Metabolic Diseases; Nutritional status; Obesity; Observations; Peptides; Physiological aspects; Plasma; Properties; Public Health; R&D; Reagents; Research & development; Risk factors; Statistical analysis; technical-report; United States; New York; United States > US

Background: The adipokine hormone, leptin, is a major component of body weight homeostasis. Numerous studies have been performed administering recombinant mouse leptin as an experimental reagent; however, the half-life of circulating leptin following exogenous administration of recombinant mouse lep...