Bacterial community structure alterations within the colorectal cancer gut microbiome

Background Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the initiation, progression, and treatment of colorectal cancer. Despite multiple studies having found significant alterations in the c...

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Published inBMC microbiology Vol. 21; no. 1; pp. 98 - 18
Main Authors Loftus, Mark, Hassouneh, Sayf Al-Deen, Yooseph, Shibu
Format Journal Article
LanguageEnglish
Published London BioMed Central 31.03.2021
BioMed Central Ltd
BMC
Subjects
Abundance
Accuracy
Amino acids
Bacteria
Biodegradation
Biodiversity
Biological Microscopy
Biomedical and Life Sciences
Biosynthesis
Cancer
Carriages
Colorectal
Colorectal cancer
Colorectal carcinoma
Community structure
Complications and side effects
Cooperation
Development and progression
Digestive system
Ecosystems
Functionals
Genomes
Gut microbiota
Health aspects
Host-bacteria relationships
Intestinal microflora
Life Sciences
Mate selection
Metagenomics
Microbiological research
Microbiology
Microbiome
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Mycology
Networks
Oral
Parasitology
Principal components analysis
Relative abundance
Research Article
Species classification
Species diversity
Structure-function relationships
Taxonomy
Tumors
Virology
Virulence
Virulence factors
United States
Metagenomics
Networks
Pathogens
Colorectal
Oral
Associations
Cancer
Microbiome
Online AccessGet full text
ISSN1471-2180
1471-2180
DOI10.1186/s12866-021-02153-x

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Abstract Background Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the initiation, progression, and treatment of colorectal cancer. Despite multiple studies having found significant alterations in the carriage of specific bacteria within the gut microbiome of colorectal cancer patients, no single bacterium has been unequivocally connected to all cases. Whether alterations in species carriages are the cause or outcome of cancer formation is still unclear, but what is clear is that focus should be placed on understanding changes to the bacterial community structure within the cancer-associated gut microbiome. Results By applying a novel set of analyses on 252 previously published whole-genome shotgun sequenced fecal samples from healthy and late-stage colorectal cancer subjects, we identify taxonomic, functional, and structural changes within the cancer-associated human gut microbiome. Bacterial association networks constructed from these data exhibited widespread differences in the underlying bacterial community structure between healthy and colorectal cancer associated gut microbiomes. Within the cancer-associated ecosystem, bacterial species were found to form associations with other species that are taxonomically and functionally dissimilar to themselves, as well as form modules functionally geared towards potential changes in the tumor-associated ecosystem. Bacterial community profiling of these samples revealed a significant increase in species diversity within the cancer-associated gut microbiome, and an elevated relative abundance of species classified as originating from the oral microbiome including, but not limited to, Fusobacterium nucleatum , Peptostreptococcus stomatis , Gemella morbillorum , and Parvimonas micra . Differential abundance analyses of community functional capabilities revealed an elevation in functions linked to virulence factors and peptide degradation, and a reduction in functions involved in amino-acid biosynthesis within the colorectal cancer gut microbiome. Conclusions We utilize whole-genome shotgun sequenced fecal samples provided from a large cohort of late-stage colorectal cancer and healthy subjects to identify a number of potentially important taxonomic, functional, and structural alterations occurring within the colorectal cancer associated gut microbiome. Our analyses indicate that the cancer-associated ecosystem influences bacterial partner selection in the native microbiota, and we highlight specific oral bacteria and their associations as potentially relevant towards aiding tumor progression.
AbstractList Background Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the initiation, progression, and treatment of colorectal cancer. Despite multiple studies having found significant alterations in the carriage of specific bacteria within the gut microbiome of colorectal cancer patients, no single bacterium has been unequivocally connected to all cases. Whether alterations in species carriages are the cause or outcome of cancer formation is still unclear, but what is clear is that focus should be placed on understanding changes to the bacterial community structure within the cancer-associated gut microbiome. Results By applying a novel set of analyses on 252 previously published whole-genome shotgun sequenced fecal samples from healthy and late-stage colorectal cancer subjects, we identify taxonomic, functional, and structural changes within the cancer-associated human gut microbiome. Bacterial association networks constructed from these data exhibited widespread differences in the underlying bacterial community structure between healthy and colorectal cancer associated gut microbiomes. Within the cancer-associated ecosystem, bacterial species were found to form associations with other species that are taxonomically and functionally dissimilar to themselves, as well as form modules functionally geared towards potential changes in the tumor-associated ecosystem. Bacterial community profiling of these samples revealed a significant increase in species diversity within the cancer-associated gut microbiome, and an elevated relative abundance of species classified as originating from the oral microbiome including, but not limited to, Fusobacterium nucleatum, Peptostreptococcus stomatis, Gemella morbillorum, and Parvimonas micra. Differential abundance analyses of community functional capabilities revealed an elevation in functions linked to virulence factors and peptide degradation, and a reduction in functions involved in amino-acid biosynthesis within the colorectal cancer gut microbiome. Conclusions We utilize whole-genome shotgun sequenced fecal samples provided from a large cohort of late-stage colorectal cancer and healthy subjects to identify a number of potentially important taxonomic, functional, and structural alterations occurring within the colorectal cancer associated gut microbiome. Our analyses indicate that the cancer-associated ecosystem influences bacterial partner selection in the native microbiota, and we highlight specific oral bacteria and their associations as potentially relevant towards aiding tumor progression. Keywords: Colorectal, Cancer, Microbiome, Metagenomics, Networks, Oral, Pathogens, Associations
Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the initiation, progression, and treatment of colorectal cancer. Despite multiple studies having found significant alterations in the carriage of specific bacteria within the gut microbiome of colorectal cancer patients, no single bacterium has been unequivocally connected to all cases. Whether alterations in species carriages are the cause or outcome of cancer formation is still unclear, but what is clear is that focus should be placed on understanding changes to the bacterial community structure within the cancer-associated gut microbiome.BACKGROUNDColorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the initiation, progression, and treatment of colorectal cancer. Despite multiple studies having found significant alterations in the carriage of specific bacteria within the gut microbiome of colorectal cancer patients, no single bacterium has been unequivocally connected to all cases. Whether alterations in species carriages are the cause or outcome of cancer formation is still unclear, but what is clear is that focus should be placed on understanding changes to the bacterial community structure within the cancer-associated gut microbiome.By applying a novel set of analyses on 252 previously published whole-genome shotgun sequenced fecal samples from healthy and late-stage colorectal cancer subjects, we identify taxonomic, functional, and structural changes within the cancer-associated human gut microbiome. Bacterial association networks constructed from these data exhibited widespread differences in the underlying bacterial community structure between healthy and colorectal cancer associated gut microbiomes. Within the cancer-associated ecosystem, bacterial species were found to form associations with other species that are taxonomically and functionally dissimilar to themselves, as well as form modules functionally geared towards potential changes in the tumor-associated ecosystem. Bacterial community profiling of these samples revealed a significant increase in species diversity within the cancer-associated gut microbiome, and an elevated relative abundance of species classified as originating from the oral microbiome including, but not limited to, Fusobacterium nucleatum, Peptostreptococcus stomatis, Gemella morbillorum, and Parvimonas micra. Differential abundance analyses of community functional capabilities revealed an elevation in functions linked to virulence factors and peptide degradation, and a reduction in functions involved in amino-acid biosynthesis within the colorectal cancer gut microbiome.RESULTSBy applying a novel set of analyses on 252 previously published whole-genome shotgun sequenced fecal samples from healthy and late-stage colorectal cancer subjects, we identify taxonomic, functional, and structural changes within the cancer-associated human gut microbiome. Bacterial association networks constructed from these data exhibited widespread differences in the underlying bacterial community structure between healthy and colorectal cancer associated gut microbiomes. Within the cancer-associated ecosystem, bacterial species were found to form associations with other species that are taxonomically and functionally dissimilar to themselves, as well as form modules functionally geared towards potential changes in the tumor-associated ecosystem. Bacterial community profiling of these samples revealed a significant increase in species diversity within the cancer-associated gut microbiome, and an elevated relative abundance of species classified as originating from the oral microbiome including, but not limited to, Fusobacterium nucleatum, Peptostreptococcus stomatis, Gemella morbillorum, and Parvimonas micra. Differential abundance analyses of community functional capabilities revealed an elevation in functions linked to virulence factors and peptide degradation, and a reduction in functions involved in amino-acid biosynthesis within the colorectal cancer gut microbiome.We utilize whole-genome shotgun sequenced fecal samples provided from a large cohort of late-stage colorectal cancer and healthy subjects to identify a number of potentially important taxonomic, functional, and structural alterations occurring within the colorectal cancer associated gut microbiome. Our analyses indicate that the cancer-associated ecosystem influences bacterial partner selection in the native microbiota, and we highlight specific oral bacteria and their associations as potentially relevant towards aiding tumor progression.CONCLUSIONSWe utilize whole-genome shotgun sequenced fecal samples provided from a large cohort of late-stage colorectal cancer and healthy subjects to identify a number of potentially important taxonomic, functional, and structural alterations occurring within the colorectal cancer associated gut microbiome. Our analyses indicate that the cancer-associated ecosystem influences bacterial partner selection in the native microbiota, and we highlight specific oral bacteria and their associations as potentially relevant towards aiding tumor progression.
Abstract Background Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the initiation, progression, and treatment of colorectal cancer. Despite multiple studies having found significant alterations in the carriage of specific bacteria within the gut microbiome of colorectal cancer patients, no single bacterium has been unequivocally connected to all cases. Whether alterations in species carriages are the cause or outcome of cancer formation is still unclear, but what is clear is that focus should be placed on understanding changes to the bacterial community structure within the cancer-associated gut microbiome. Results By applying a novel set of analyses on 252 previously published whole-genome shotgun sequenced fecal samples from healthy and late-stage colorectal cancer subjects, we identify taxonomic, functional, and structural changes within the cancer-associated human gut microbiome. Bacterial association networks constructed from these data exhibited widespread differences in the underlying bacterial community structure between healthy and colorectal cancer associated gut microbiomes. Within the cancer-associated ecosystem, bacterial species were found to form associations with other species that are taxonomically and functionally dissimilar to themselves, as well as form modules functionally geared towards potential changes in the tumor-associated ecosystem. Bacterial community profiling of these samples revealed a significant increase in species diversity within the cancer-associated gut microbiome, and an elevated relative abundance of species classified as originating from the oral microbiome including, but not limited to, Fusobacterium nucleatum, Peptostreptococcus stomatis, Gemella morbillorum, and Parvimonas micra. Differential abundance analyses of community functional capabilities revealed an elevation in functions linked to virulence factors and peptide degradation, and a reduction in functions involved in amino-acid biosynthesis within the colorectal cancer gut microbiome. Conclusions We utilize whole-genome shotgun sequenced fecal samples provided from a large cohort of late-stage colorectal cancer and healthy subjects to identify a number of potentially important taxonomic, functional, and structural alterations occurring within the colorectal cancer associated gut microbiome. Our analyses indicate that the cancer-associated ecosystem influences bacterial partner selection in the native microbiota, and we highlight specific oral bacteria and their associations as potentially relevant towards aiding tumor progression.
Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the initiation, progression, and treatment of colorectal cancer. Despite multiple studies having found significant alterations in the carriage of specific bacteria within the gut microbiome of colorectal cancer patients, no single bacterium has been unequivocally connected to all cases. Whether alterations in species carriages are the cause or outcome of cancer formation is still unclear, but what is clear is that focus should be placed on understanding changes to the bacterial community structure within the cancer-associated gut microbiome. By applying a novel set of analyses on 252 previously published whole-genome shotgun sequenced fecal samples from healthy and late-stage colorectal cancer subjects, we identify taxonomic, functional, and structural changes within the cancer-associated human gut microbiome. Bacterial association networks constructed from these data exhibited widespread differences in the underlying bacterial community structure between healthy and colorectal cancer associated gut microbiomes. Within the cancer-associated ecosystem, bacterial species were found to form associations with other species that are taxonomically and functionally dissimilar to themselves, as well as form modules functionally geared towards potential changes in the tumor-associated ecosystem. Bacterial community profiling of these samples revealed a significant increase in species diversity within the cancer-associated gut microbiome, and an elevated relative abundance of species classified as originating from the oral microbiome including, but not limited to, Fusobacterium nucleatum, Peptostreptococcus stomatis, Gemella morbillorum, and Parvimonas micra. Differential abundance analyses of community functional capabilities revealed an elevation in functions linked to virulence factors and peptide degradation, and a reduction in functions involved in amino-acid biosynthesis within the colorectal cancer gut microbiome. We utilize whole-genome shotgun sequenced fecal samples provided from a large cohort of late-stage colorectal cancer and healthy subjects to identify a number of potentially important taxonomic, functional, and structural alterations occurring within the colorectal cancer associated gut microbiome. Our analyses indicate that the cancer-associated ecosystem influences bacterial partner selection in the native microbiota, and we highlight specific oral bacteria and their associations as potentially relevant towards aiding tumor progression.
Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the initiation, progression, and treatment of colorectal cancer. Despite multiple studies having found significant alterations in the carriage of specific bacteria within the gut microbiome of colorectal cancer patients, no single bacterium has been unequivocally connected to all cases. Whether alterations in species carriages are the cause or outcome of cancer formation is still unclear, but what is clear is that focus should be placed on understanding changes to the bacterial community structure within the cancer-associated gut microbiome. By applying a novel set of analyses on 252 previously published whole-genome shotgun sequenced fecal samples from healthy and late-stage colorectal cancer subjects, we identify taxonomic, functional, and structural changes within the cancer-associated human gut microbiome. Bacterial association networks constructed from these data exhibited widespread differences in the underlying bacterial community structure between healthy and colorectal cancer associated gut microbiomes. Within the cancer-associated ecosystem, bacterial species were found to form associations with other species that are taxonomically and functionally dissimilar to themselves, as well as form modules functionally geared towards potential changes in the tumor-associated ecosystem. Bacterial community profiling of these samples revealed a significant increase in species diversity within the cancer-associated gut microbiome, and an elevated relative abundance of species classified as originating from the oral microbiome including, but not limited to, Fusobacterium nucleatum, Peptostreptococcus stomatis, Gemella morbillorum, and Parvimonas micra. Differential abundance analyses of community functional capabilities revealed an elevation in functions linked to virulence factors and peptide degradation, and a reduction in functions involved in amino-acid biosynthesis within the colorectal cancer gut microbiome. We utilize whole-genome shotgun sequenced fecal samples provided from a large cohort of late-stage colorectal cancer and healthy subjects to identify a number of potentially important taxonomic, functional, and structural alterations occurring within the colorectal cancer associated gut microbiome. Our analyses indicate that the cancer-associated ecosystem influences bacterial partner selection in the native microbiota, and we highlight specific oral bacteria and their associations as potentially relevant towards aiding tumor progression.
Background Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the initiation, progression, and treatment of colorectal cancer. Despite multiple studies having found significant alterations in the carriage of specific bacteria within the gut microbiome of colorectal cancer patients, no single bacterium has been unequivocally connected to all cases. Whether alterations in species carriages are the cause or outcome of cancer formation is still unclear, but what is clear is that focus should be placed on understanding changes to the bacterial community structure within the cancer-associated gut microbiome. Results By applying a novel set of analyses on 252 previously published whole-genome shotgun sequenced fecal samples from healthy and late-stage colorectal cancer subjects, we identify taxonomic, functional, and structural changes within the cancer-associated human gut microbiome. Bacterial association networks constructed from these data exhibited widespread differences in the underlying bacterial community structure between healthy and colorectal cancer associated gut microbiomes. Within the cancer-associated ecosystem, bacterial species were found to form associations with other species that are taxonomically and functionally dissimilar to themselves, as well as form modules functionally geared towards potential changes in the tumor-associated ecosystem. Bacterial community profiling of these samples revealed a significant increase in species diversity within the cancer-associated gut microbiome, and an elevated relative abundance of species classified as originating from the oral microbiome including, but not limited to, Fusobacterium nucleatum, Peptostreptococcus stomatis, Gemella morbillorum, and Parvimonas micra. Differential abundance analyses of community functional capabilities revealed an elevation in functions linked to virulence factors and peptide degradation, and a reduction in functions involved in amino-acid biosynthesis within the colorectal cancer gut microbiome. Conclusions We utilize whole-genome shotgun sequenced fecal samples provided from a large cohort of late-stage colorectal cancer and healthy subjects to identify a number of potentially important taxonomic, functional, and structural alterations occurring within the colorectal cancer associated gut microbiome. Our analyses indicate that the cancer-associated ecosystem influences bacterial partner selection in the native microbiota, and we highlight specific oral bacteria and their associations as potentially relevant towards aiding tumor progression.
Background Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the initiation, progression, and treatment of colorectal cancer. Despite multiple studies having found significant alterations in the carriage of specific bacteria within the gut microbiome of colorectal cancer patients, no single bacterium has been unequivocally connected to all cases. Whether alterations in species carriages are the cause or outcome of cancer formation is still unclear, but what is clear is that focus should be placed on understanding changes to the bacterial community structure within the cancer-associated gut microbiome. Results By applying a novel set of analyses on 252 previously published whole-genome shotgun sequenced fecal samples from healthy and late-stage colorectal cancer subjects, we identify taxonomic, functional, and structural changes within the cancer-associated human gut microbiome. Bacterial association networks constructed from these data exhibited widespread differences in the underlying bacterial community structure between healthy and colorectal cancer associated gut microbiomes. Within the cancer-associated ecosystem, bacterial species were found to form associations with other species that are taxonomically and functionally dissimilar to themselves, as well as form modules functionally geared towards potential changes in the tumor-associated ecosystem. Bacterial community profiling of these samples revealed a significant increase in species diversity within the cancer-associated gut microbiome, and an elevated relative abundance of species classified as originating from the oral microbiome including, but not limited to, Fusobacterium nucleatum , Peptostreptococcus stomatis , Gemella morbillorum , and Parvimonas micra . Differential abundance analyses of community functional capabilities revealed an elevation in functions linked to virulence factors and peptide degradation, and a reduction in functions involved in amino-acid biosynthesis within the colorectal cancer gut microbiome. Conclusions We utilize whole-genome shotgun sequenced fecal samples provided from a large cohort of late-stage colorectal cancer and healthy subjects to identify a number of potentially important taxonomic, functional, and structural alterations occurring within the colorectal cancer associated gut microbiome. Our analyses indicate that the cancer-associated ecosystem influences bacterial partner selection in the native microbiota, and we highlight specific oral bacteria and their associations as potentially relevant towards aiding tumor progression.
ArticleNumber 98
Audience Academic
Author Hassouneh, Sayf Al-Deen
Yooseph, Shibu
Loftus, Mark
Author_xml – sequence: 1
  givenname: Mark
  surname: Loftus
  fullname: Loftus, Mark
  organization: Burnett School of Biomedical Sciences, Genomics and Bioinformatics Cluster, University of Central Florida
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  givenname: Sayf Al-Deen
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  fullname: Hassouneh, Sayf Al-Deen
  organization: Burnett School of Biomedical Sciences, Genomics and Bioinformatics Cluster, University of Central Florida
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  surname: Yooseph
  fullname: Yooseph, Shibu
  email: Shibu.Yooseph@ucf.edu
  organization: Department of Computer Science, Genomics and Bioinformatics Cluster, University of Central Florida
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33789570$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1126/science.aao3290
10.1186/1471-2105-11-119
10.1093/epirev/mxx006
10.1038/s41522-017-0040-3
10.1103/PhysRevE.70.066111
10.1093/annonc/mdq653
10.1002/ijc.30486
10.1099/00207713-49-4-1375
10.3390/nu7042930
10.1038/s41591-019-0458-7
10.3389/fmicb.2018.01835
10.1111/j.2517-6161.1995.tb02031.x
10.1038/nmeth.1923
10.1038/ctg.2016.53
10.1111/j.2517-6161.1982.tb01195.x
10.1097/MCO.0000000000000121
10.1371/journal.pbio.1002533
10.1016/0092-8674(90)90186-I
10.1038/nri2850
10.1016/j.ics.2005.06.071
10.1038/nature12138
10.1073/pnas.1809349115
10.1093/biostatistics/kxm045
10.1016/j.cell.2016.05.041
10.1093/nar/gky995
10.1039/C8NP00009C
10.1016/j.anaerobe.2018.10.007
10.3389/fmicb.2019.00826
10.1136/gutjnl-2015-309595
10.1158/0008-5472.CAN-14-2211
10.1093/nar/29.1.41
10.1053/j.gastro.2010.01.054
10.1093/acprof:oso/9780199206650.001.0001
10.3322/caac.21601
10.1038/nature18847
10.1034/j.1399-302x.2000.150410.x
10.1128/JCM.40.10.3871-3873.2002
10.1093/bioinformatics/btu031
10.1016/j.cell.2017.07.008
10.1128/mSystems.00187-18
10.3389/fmicb.2017.02224
10.1085/jgp.8.6.519
10.1016/j.micinf.2015.03.011
10.1038/nrc704
10.1038/nrmicro2819
10.3390/nu11010164
10.1016/j.bbrc.2015.12.083
10.1101/gr.126573.111
10.11138/orl/2017.10.3.229
10.1001/jama.2008.839
10.1038/nrmicro2259
10.1186/1471-2180-10-66
10.1371/journal.pcbi.1004226
10.1177/1533033819867354
10.1186/s13073-016-0290-3
10.1371/journal.pone.0027992
10.1038/nrc.2017.77
10.1186/1471-2105-8-25
10.1073/pnas.0712345105
10.3389/fcimb.2012.00086
10.1093/bioinformatics/btu170
10.1093/bioinformatics/btt656
10.1126/science.aan4236
10.1136/gutjnl-2017-314814
10.1214/aoms/1177730491
10.1093/jnci/djt300
10.1080/19490976.2016.1241933
10.1016/j.anaerobe.2019.102100
10.1093/jinfdis/jiq061
10.1038/s41591-019-0405-7
10.1038/nrmicro2334
10.1128/AEM.69.11.6354-6360.2003
10.1038/ncomms7528
10.1097/MD.0000000000012244
10.1053/j.gastro.2016.11.018
10.1034/j.1600-0757.2002.280102.x
10.1038/s41568-018-0048-x
10.15252/embr.201847638
10.1186/2049-2618-1-16
10.3748/wjg.v17.i12.1519
10.1038/nri2515
10.1016/j.molmed.2016.11.004
10.1038/nature11550
10.1038/ismej.2011.24
10.1093/nar/gkt1209
10.1128/JB.00838-09
10.21203/rs.2.21627/v1
10.1371/journal.pcbi.1002358
10.1038/s41598-021-82449-0
10.7717/peerj.4652
10.1002/eji.201444972
10.7717/peerj.3889
10.4103/jid.jid_4_19
10.1111/j.1432-1033.1977.tb11987.x
10.1074/jbc.M611567200
10.1016/j.cmet.2017.04.001
10.1186/s40168-018-0451-2
10.1093/nar/gkv1189
10.1038/oncsis.2015.49
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Issue 1
Keywords Metagenomics
Networks
Pathogens
Colorectal
Oral
Associations
Cancer
Microbiome
Language English
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References A Horiuchi (2153_CR39) 2020; 62
J Aitchison (2153_CR24) 1982; 44
2153_CR81
2153_CR86
2153_CR85
Q Feng (2153_CR5) 2015; 6
P Jones (2153_CR99) 2014; 30
E Botteri (2153_CR12) 2008; 300
JL Round (2153_CR51) 2009; 9
E Neis (2153_CR79) 2015; 7
ER Fearon (2153_CR13) 1990; 61
P Yilmaz (2153_CR65) 2014; 42
V Gopalakrishnan (2153_CR19) 2018; 359
M Xu (2153_CR84) 2007; 282
HB Mann (2153_CR106) 1947; 18
R Loomba (2153_CR67) 2017; 25
AL Gould (2153_CR22) 2018; 115
O Tsoy (2153_CR89) 2009; 191
I Chattopadhyay (2153_CR41) 2019; 18
SS Socransky (2153_CR77) 2002; 28
2153_CR93
D Lee (2153_CR43) 2018; 97
2153_CR97
2153_CR96
V Fedirko (2153_CR10) 2011; 22
R Sender (2153_CR1) 2016; 14
AD Kostic (2153_CR7) 2012; 22
B Flemer (2153_CR28) 2017; 66
D Hyatt (2153_CR98) 2010; 11
S Abubucker (2153_CR78) 2012; 8
N Cerf-Bensussan (2153_CR52) 2010; 10
C Commisso (2153_CR61) 2013; 497
R Ranjan (2153_CR32) 2016; 469
B Flemer (2153_CR71) 2018; 67
Z Dai (2153_CR74) 2018; 6
N Takahashi (2153_CR76) 2005; 1284
ME Hibbing (2153_CR21) 2010; 8
J Friedman (2153_CR33) 2008; 9
MJ Hopkins (2153_CR80) 2003; 69
NA O’Leary (2153_CR66) 2016; 44
2153_CR27
2153_CR25
2153_CR105
2153_CR103
2153_CR102
2153_CR101
AL Harris (2153_CR58) 2002; 2
KV-A Johnson (2153_CR34) 2016; 7
B Langmead (2153_CR92) 2012; 9
RC Edgar (2153_CR30) 2018; 6
O Warburg (2153_CR60) 1927; 8
J Ahn (2153_CR4) 2013; 105
DH Haft (2153_CR47) 2001; 29
S El-Gebali (2153_CR48) 2019; 47
CA Lozupone (2153_CR55) 2012; 489
BT Finicle (2153_CR64) 2018; 18
A Dzutsev (2153_CR15) 2015; 45
LC Xia (2153_CR94) 2011; 6
D Ai (2153_CR26) 2019; 10
A Koh (2153_CR82) 2016; 165
DS Michaud (2153_CR44) 2017; 39
S Schlafer (2153_CR40) 2010; 10
2153_CR46
F Momen-Heravi (2153_CR42) 2017; 140
JA Steele (2153_CR54) 2011; 5
RC Edgar (2153_CR57) 2017; 5
Y Benjamini (2153_CR107) 1995; 57
2153_CR49
RL Siegel (2153_CR8) 2020; 70
V Matson (2153_CR20) 2018; 359
GB Gloor (2153_CR23) 2017; 8
RL Warren (2153_CR29) 2013; 1
JM Phang (2153_CR87) 2015; 18
RB Canani (2153_CR83) 2011; 17
2153_CR53
AM Thomas (2153_CR56) 2019; 25
C Strobl (2153_CR35) 2007; 8
NT Baxter (2153_CR75) 2016; 8
S Yachida (2153_CR31) 2019; 25
K Thanikachalam (2153_CR11) 2019; 11
A Contreras (2153_CR37) 2000; 15
P Oswal (2153_CR36) 2020; 10
S Li (2153_CR6) 2017; 23
S Jones (2153_CR9) 2008; 105
J Neilands (2153_CR38) 2019; 55
2153_CR63
CA Thaiss (2153_CR3) 2016; 535
2153_CR62
JM Rousee (2153_CR70) 2002; 40
T Yu (2153_CR16) 2017; 170
Y Liao (2153_CR100) 2014; 30
KW Jasperson (2153_CR14) 2010; 138
2153_CR69
C Corbet (2153_CR59) 2017; 17
ZY Kho (2153_CR2) 2018; 9
AW Aruni (2153_CR68) 2015; 17
DA Garsin (2153_CR90) 2010; 8
CL Sears (2153_CR18) 2011; 203
D Lauritano (2153_CR45) 2017; 10
A Clauset (2153_CR104) 2004; 70
2153_CR73
2153_CR72
SN Dixit (2153_CR88) 1977; 81
AM Bolger (2153_CR91) 2014; 30
M Loftus (2153_CR95) 2021; 11
H Tjalsma (2153_CR17) 2012; 10
G D’Souza (2153_CR50) 2018; 35
References_xml – volume: 359
  start-page: 104
  issue: 6371
  year: 2018
  ident: 2153_CR20
  publication-title: Science.
  doi: 10.1126/science.aao3290
– volume: 11
  start-page: 119
  issue: 1
  year: 2010
  ident: 2153_CR98
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-11-119
– volume: 39
  start-page: 49
  issue: 1
  year: 2017
  ident: 2153_CR44
  publication-title: Epidemiol Rev
  doi: 10.1093/epirev/mxx006
– ident: 2153_CR73
  doi: 10.1038/s41522-017-0040-3
– volume: 70
  issue: 6
  year: 2004
  ident: 2153_CR104
  publication-title: Phys Rev E
  doi: 10.1103/PhysRevE.70.066111
– volume: 22
  start-page: 1958
  issue: 9
  year: 2011
  ident: 2153_CR10
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdq653
– volume: 140
  start-page: 646
  issue: 3
  year: 2017
  ident: 2153_CR42
  publication-title: Int J Cancer
  doi: 10.1002/ijc.30486
– ident: 2153_CR69
  doi: 10.1099/00207713-49-4-1375
– volume: 7
  start-page: 2930
  issue: 4
  year: 2015
  ident: 2153_CR79
  publication-title: Nutrients.
  doi: 10.3390/nu7042930
– volume: 25
  start-page: 968
  issue: 6
  year: 2019
  ident: 2153_CR31
  publication-title: Nat Med
  doi: 10.1038/s41591-019-0458-7
– ident: 2153_CR49
– ident: 2153_CR101
– volume: 9
  start-page: 1835
  year: 2018
  ident: 2153_CR2
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2018.01835
– volume: 57
  start-page: 289
  issue: 1
  year: 1995
  ident: 2153_CR107
  publication-title: J R Stat Soc Ser B Methodol
  doi: 10.1111/j.2517-6161.1995.tb02031.x
– volume: 9
  start-page: 357
  issue: 4
  year: 2012
  ident: 2153_CR92
  publication-title: Nat Methods
  doi: 10.1038/nmeth.1923
– ident: 2153_CR93
– ident: 2153_CR72
  doi: 10.1038/ctg.2016.53
– volume: 44
  start-page: 139
  issue: 2
  year: 1982
  ident: 2153_CR24
  publication-title: J R Stat Soc Ser B Methodol
  doi: 10.1111/j.2517-6161.1982.tb01195.x
– volume: 18
  start-page: 71
  issue: 1
  year: 2015
  ident: 2153_CR87
  publication-title: Curr Opin Clin Nutr Metabolic Care
  doi: 10.1097/MCO.0000000000000121
– volume: 14
  issue: 8
  year: 2016
  ident: 2153_CR1
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.1002533
– volume: 61
  start-page: 759
  issue: 5
  year: 1990
  ident: 2153_CR13
  publication-title: Cell.
  doi: 10.1016/0092-8674(90)90186-I
– volume: 10
  start-page: 735
  issue: 10
  year: 2010
  ident: 2153_CR52
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2850
– volume: 1284
  start-page: 103
  year: 2005
  ident: 2153_CR76
  publication-title: Int Congr Ser
  doi: 10.1016/j.ics.2005.06.071
– volume: 497
  start-page: 633
  issue: 7451
  year: 2013
  ident: 2153_CR61
  publication-title: Nature.
  doi: 10.1038/nature12138
– volume: 115
  start-page: E11951
  issue: 51
  year: 2018
  ident: 2153_CR22
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1809349115
– volume: 9
  start-page: 432
  issue: 3
  year: 2008
  ident: 2153_CR33
  publication-title: Biostatistics.
  doi: 10.1093/biostatistics/kxm045
– volume: 165
  start-page: 1332
  issue: 6
  year: 2016
  ident: 2153_CR82
  publication-title: Cell.
  doi: 10.1016/j.cell.2016.05.041
– volume: 47
  start-page: D427
  issue: D1
  year: 2019
  ident: 2153_CR48
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gky995
– volume: 35
  start-page: 455
  issue: 5
  year: 2018
  ident: 2153_CR50
  publication-title: Nat Prod Rep
  doi: 10.1039/C8NP00009C
– volume: 55
  start-page: 54
  year: 2019
  ident: 2153_CR38
  publication-title: Anaerobe.
  doi: 10.1016/j.anaerobe.2018.10.007
– volume: 10
  start-page: 826
  year: 2019
  ident: 2153_CR26
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2019.00826
– volume: 66
  start-page: 633
  issue: 4
  year: 2017
  ident: 2153_CR28
  publication-title: Gut.
  doi: 10.1136/gutjnl-2015-309595
– ident: 2153_CR62
  doi: 10.1158/0008-5472.CAN-14-2211
– volume: 29
  start-page: 41
  issue: 1
  year: 2001
  ident: 2153_CR47
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/29.1.41
– volume: 138
  start-page: 2044
  issue: 6
  year: 2010
  ident: 2153_CR14
  publication-title: Gastroenterology.
  doi: 10.1053/j.gastro.2010.01.054
– ident: 2153_CR53
  doi: 10.1093/acprof:oso/9780199206650.001.0001
– volume: 70
  start-page: 145
  issue: 3
  year: 2020
  ident: 2153_CR8
  publication-title: CA A Cancer J Clin
  doi: 10.3322/caac.21601
– volume: 535
  start-page: 65
  issue: 7610
  year: 2016
  ident: 2153_CR3
  publication-title: Nature.
  doi: 10.1038/nature18847
– volume: 15
  start-page: 269
  issue: 4
  year: 2000
  ident: 2153_CR37
  publication-title: Oral Microbiol Immunol
  doi: 10.1034/j.1399-302x.2000.150410.x
– volume: 40
  start-page: 3871
  issue: 10
  year: 2002
  ident: 2153_CR70
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.40.10.3871-3873.2002
– volume: 30
  start-page: 1236
  issue: 9
  year: 2014
  ident: 2153_CR99
  publication-title: Bioinformatics.
  doi: 10.1093/bioinformatics/btu031
– volume: 170
  start-page: 548
  issue: 3
  year: 2017
  ident: 2153_CR16
  publication-title: Cell
  doi: 10.1016/j.cell.2017.07.008
– ident: 2153_CR46
  doi: 10.1128/mSystems.00187-18
– volume: 8
  start-page: 2224
  year: 2017
  ident: 2153_CR23
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2017.02224
– volume: 8
  start-page: 519
  issue: 6
  year: 1927
  ident: 2153_CR60
  publication-title: J Gen Physiol
  doi: 10.1085/jgp.8.6.519
– volume: 17
  start-page: 517
  issue: 7
  year: 2015
  ident: 2153_CR68
  publication-title: Microbes Infect
  doi: 10.1016/j.micinf.2015.03.011
– volume: 2
  start-page: 38
  issue: 1
  year: 2002
  ident: 2153_CR58
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc704
– volume: 10
  start-page: 575
  issue: 8
  year: 2012
  ident: 2153_CR17
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro2819
– volume: 11
  start-page: 164
  issue: 1
  year: 2019
  ident: 2153_CR11
  publication-title: Nutrients.
  doi: 10.3390/nu11010164
– volume: 469
  start-page: 967
  issue: 4
  year: 2016
  ident: 2153_CR32
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2015.12.083
– ident: 2153_CR102
– volume: 22
  start-page: 292
  issue: 2
  year: 2012
  ident: 2153_CR7
  publication-title: Genome Res
  doi: 10.1101/gr.126573.111
– volume: 10
  start-page: 229
  issue: 3
  year: 2017
  ident: 2153_CR45
  publication-title: ORL.
  doi: 10.11138/orl/2017.10.3.229
– volume: 300
  start-page: 2765
  issue: 23
  year: 2008
  ident: 2153_CR12
  publication-title: JAMA.
  doi: 10.1001/jama.2008.839
– volume: 8
  start-page: 15
  issue: 1
  year: 2010
  ident: 2153_CR21
  publication-title: Nat Rev Microbiol.
  doi: 10.1038/nrmicro2259
– volume: 10
  start-page: 66
  issue: 1
  year: 2010
  ident: 2153_CR40
  publication-title: BMC Microbiol
  doi: 10.1186/1471-2180-10-66
– ident: 2153_CR25
  doi: 10.1371/journal.pcbi.1004226
– volume: 18
  start-page: 153303381986735
  year: 2019
  ident: 2153_CR41
  publication-title: Technol Cancer Res Treat
  doi: 10.1177/1533033819867354
– volume: 8
  start-page: 37
  issue: 1
  year: 2016
  ident: 2153_CR75
  publication-title: Genome Med
  doi: 10.1186/s13073-016-0290-3
– volume: 6
  start-page: e27992
  issue: 12
  year: 2011
  ident: 2153_CR94
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0027992
– volume: 17
  start-page: 577
  issue: 10
  year: 2017
  ident: 2153_CR59
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc.2017.77
– volume: 8
  start-page: 25
  issue: 1
  year: 2007
  ident: 2153_CR35
  publication-title: BMC Bioinformatics.
  doi: 10.1186/1471-2105-8-25
– ident: 2153_CR105
– volume: 105
  start-page: 4283
  issue: 11
  year: 2008
  ident: 2153_CR9
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.0712345105
– ident: 2153_CR81
  doi: 10.3389/fcimb.2012.00086
– volume: 30
  start-page: 2114
  issue: 15
  year: 2014
  ident: 2153_CR91
  publication-title: Bioinformatics.
  doi: 10.1093/bioinformatics/btu170
– volume: 30
  start-page: 923
  issue: 7
  year: 2014
  ident: 2153_CR100
  publication-title: Bioinformatics.
  doi: 10.1093/bioinformatics/btt656
– volume: 359
  start-page: 97
  issue: 6371
  year: 2018
  ident: 2153_CR19
  publication-title: Science.
  doi: 10.1126/science.aan4236
– volume: 67
  start-page: 1454
  issue: 8
  year: 2018
  ident: 2153_CR71
  publication-title: Gut.
  doi: 10.1136/gutjnl-2017-314814
– volume: 18
  start-page: 50
  issue: 1
  year: 1947
  ident: 2153_CR106
  publication-title: Ann Math Statist
  doi: 10.1214/aoms/1177730491
– ident: 2153_CR97
– volume: 105
  start-page: 1907
  issue: 24
  year: 2013
  ident: 2153_CR4
  publication-title: JNCI: Journal of the National Cancer Institute
  doi: 10.1093/jnci/djt300
– volume: 7
  start-page: 455
  issue: 6
  year: 2016
  ident: 2153_CR34
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2016.1241933
– volume: 62
  start-page: 102100
  year: 2020
  ident: 2153_CR39
  publication-title: Anaerobe.
  doi: 10.1016/j.anaerobe.2019.102100
– volume: 203
  start-page: 306
  issue: 3
  year: 2011
  ident: 2153_CR18
  publication-title: J Infect Dis
  doi: 10.1093/jinfdis/jiq061
– volume: 25
  start-page: 667
  issue: 4
  year: 2019
  ident: 2153_CR56
  publication-title: Nat Med
  doi: 10.1038/s41591-019-0405-7
– volume: 8
  start-page: 290
  issue: 4
  year: 2010
  ident: 2153_CR90
  publication-title: Nat Rev Microbiol.
  doi: 10.1038/nrmicro2334
– volume: 69
  start-page: 6354
  issue: 11
  year: 2003
  ident: 2153_CR80
  publication-title: AEM.
  doi: 10.1128/AEM.69.11.6354-6360.2003
– volume: 6
  start-page: 6528
  issue: 1
  year: 2015
  ident: 2153_CR5
  publication-title: Nat Commun
  doi: 10.1038/ncomms7528
– volume: 97
  issue: 37
  year: 2018
  ident: 2153_CR43
  publication-title: Medicine.
  doi: 10.1097/MD.0000000000012244
– ident: 2153_CR86
  doi: 10.1053/j.gastro.2016.11.018
– volume: 28
  start-page: 12
  issue: 1
  year: 2002
  ident: 2153_CR77
  publication-title: Periodontology 2000
  doi: 10.1034/j.1600-0757.2002.280102.x
– volume: 18
  start-page: 619
  issue: 10
  year: 2018
  ident: 2153_CR64
  publication-title: Nat Rev Cancer
  doi: 10.1038/s41568-018-0048-x
– ident: 2153_CR85
  doi: 10.15252/embr.201847638
– ident: 2153_CR96
– volume: 1
  start-page: 16
  issue: 1
  year: 2013
  ident: 2153_CR29
  publication-title: Microbiome.
  doi: 10.1186/2049-2618-1-16
– volume: 17
  start-page: 1519
  issue: 12
  year: 2011
  ident: 2153_CR83
  publication-title: WJG.
  doi: 10.3748/wjg.v17.i12.1519
– volume: 9
  start-page: 313
  issue: 5
  year: 2009
  ident: 2153_CR51
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2515
– volume: 23
  start-page: 18
  issue: 1
  year: 2017
  ident: 2153_CR6
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2016.11.004
– ident: 2153_CR103
– volume: 489
  start-page: 220
  issue: 7415
  year: 2012
  ident: 2153_CR55
  publication-title: Nature.
  doi: 10.1038/nature11550
– volume: 5
  start-page: 1414
  issue: 9
  year: 2011
  ident: 2153_CR54
  publication-title: ISME J
  doi: 10.1038/ismej.2011.24
– volume: 42
  start-page: D643
  issue: D1
  year: 2014
  ident: 2153_CR65
  publication-title: Nucl Acids Res
  doi: 10.1093/nar/gkt1209
– volume: 191
  start-page: 7157
  issue: 23
  year: 2009
  ident: 2153_CR89
  publication-title: JB.
  doi: 10.1128/JB.00838-09
– ident: 2153_CR27
  doi: 10.21203/rs.2.21627/v1
– volume: 8
  issue: 6
  year: 2012
  ident: 2153_CR78
  publication-title: PLoS Comput Biol
  doi: 10.1371/journal.pcbi.1002358
– volume: 11
  start-page: 2828
  issue: 1
  year: 2021
  ident: 2153_CR95
  publication-title: Sci Rep
  doi: 10.1038/s41598-021-82449-0
– volume: 6
  start-page: e4652
  year: 2018
  ident: 2153_CR30
  publication-title: PeerJ.
  doi: 10.7717/peerj.4652
– volume: 45
  start-page: 17
  issue: 1
  year: 2015
  ident: 2153_CR15
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201444972
– volume: 5
  year: 2017
  ident: 2153_CR57
  publication-title: PeerJ.
  doi: 10.7717/peerj.3889
– volume: 10
  start-page: 17
  issue: 1
  year: 2020
  ident: 2153_CR36
  publication-title: J Interdiscip Dentistry
  doi: 10.4103/jid.jid_4_19
– volume: 81
  start-page: 599
  issue: 3
  year: 1977
  ident: 2153_CR88
  publication-title: Eur J Biochem
  doi: 10.1111/j.1432-1033.1977.tb11987.x
– volume: 282
  start-page: 25000
  issue: 34
  year: 2007
  ident: 2153_CR84
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M611567200
– volume: 25
  start-page: 1054
  issue: 5
  year: 2017
  ident: 2153_CR67
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2017.04.001
– volume: 6
  start-page: 70
  issue: 1
  year: 2018
  ident: 2153_CR74
  publication-title: Microbiome.
  doi: 10.1186/s40168-018-0451-2
– volume: 44
  start-page: D733
  issue: D1
  year: 2016
  ident: 2153_CR66
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkv1189
– ident: 2153_CR63
  doi: 10.1038/oncsis.2015.49
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Snippet Background Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for...
Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the...
Background Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for...
Abstract Background Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for...
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SubjectTerms Abundance
Accuracy
Amino acids
Bacteria
Biodegradation
Biodiversity
Biological Microscopy
Biomedical and Life Sciences
Biosynthesis
Cancer
Carriages
Colorectal
Colorectal cancer
Colorectal carcinoma
Community structure
Complications and side effects
Cooperation
Development and progression
Digestive system
Ecosystems
Functionals
Genomes
Gut microbiota
Health aspects
Host-bacteria relationships
Intestinal microflora
Life Sciences
Mate selection
Metagenomics
Microbiological research
Microbiology
Microbiome
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Mycology
Networks
Oral
Parasitology
Principal components analysis
Relative abundance
Research Article
Species classification
Species diversity
Structure-function relationships
Taxonomy
Tumors
Virology
Virulence
Virulence factors
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Title Bacterial community structure alterations within the colorectal cancer gut microbiome
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https://www.ncbi.nlm.nih.gov/pubmed/33789570
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https://pubmed.ncbi.nlm.nih.gov/PMC8011136
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Volume 21
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