Impaired Expression of the Inducible cAMP Early Repressor Accounts for Sustained Adipose CREB Activity in Obesity

• Published in: Diabetes (New York, N.Y.) Vol. 60; no. 12; pp. 3169 - 3174
• Main Authors: Favre, Dimitri, Le Gouill, Eric, Fahmi, Denis, Verdumo, Chantal, Chinetti-Gbaguidi, Giulia, Staels, Bart, Caiazzo, Robert, Pattou, François, Lê, Kim-Anne, Tappy, Luc, Regazzi, Romano, Giusti, Vittorio, Vollenweider, Peter, Waeber, Gérard, Abderrahmani, Amar
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.12.2011
• Subjects: 3T3-L1 Cells; Activating Transcription Factor 3 - genetics; Activating Transcription Factor 3 - metabolism; Adipocytes; Adiponectin - genetics; Adiponectin - metabolism; Adipose tissue; Adipose Tissue, White - metabolism; Adipose tissues; Animals; Biological and medical sciences; Blotting, Western; Body fat; Cyclic adenosine monophosphate; Cyclic adenylic acid; Cyclic AMP Response Element Modulator - genetics; Cyclic AMP Response Element Modulator - metabolism; Cyclic AMP Response Element-Binding Protein - genetics; Cyclic AMP Response Element-Binding Protein - metabolism; Diabetes; Diabetes. Impaired glucose tolerance; Diet; Electrophoretic Mobility Shift Assay; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Genes; Genetic aspects; Glucose; Glucose Transporter Type 4 - genetics; Glucose Transporter Type 4 - metabolism; Humans; Insulin resistance; Intra-Abdominal Fat - metabolism; Male; Medical sciences; Metabolic diseases; Mice; Mice, Inbred C57BL; Obesity; Obesity - genetics; Obesity - metabolism; Obesity Studies; Physiological aspects; Proteins; Real-Time Polymerase Chain Reaction; Research design; Risk factors; Transcription factors; White people; France; Endocrinopathy; Cyclic AMP; Obesity; Diabetes mellitus; Nutritional status; Nutrition disorder

Increase in adipose cAMP-responsive element binding protein (CREB) activity promotes adipocyte dysfunction and systemic insulin resistance in obese mice. This is achieved by increasing the expression of activating transcription factor 3 (ATF3). In this study, we investigated whether impaired express...