Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia

• Published in: Schizophrenia research Vol. 167; no. 1-3; pp. 18 - 27
• Main Authors: Berretta, Sabina, Pantazopoulos, Harry, Markota, Matej, Brown, Christopher, Batzianouli, Eleni T.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2015
• Subjects: Amygdala; Animals; Brain - pathology; Entorhinal cortex; Extracellular matrix; Extracellular Matrix - pathology; gamma-Aminobutyric Acid - metabolism; Humans; Interneurons - pathology; Interneurons - physiology; Perineuronal nets; Prefrontal cortex; Psychiatry; Schizophrenia; Schizophrenia - pathology; Schizophrenia; Extracellular matrix; Perineuronal nets; Prefrontal cortex; Amygdala; Entorhinal cortex

Perineuronal nets (PNNs) were shown to be markedly altered in subjects with schizophrenia. In particular, decreases of PNNs have been detected in the amygdala, entorhinal cortex and prefrontal cortex. The formation of these specialized extracellular matrix (ECM) aggregates during postnatal developme...