Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes

• Published in: Nature (London) Vol. 483; no. 7387; pp. 82 - 86
• Main Authors: Hughes, Jennifer F., Skaletsky, Helen, Brown, Laura G., Pyntikova, Tatyana, Graves, Tina, Fulton, Robert S., Dugan, Shannon, Ding, Yan, Buhay, Christian J., Kremitzki, Colin, Wang, Qiaoyan, Shen, Hua, Holder, Michael, Villasana, Donna, Nazareth, Lynne V., Cree, Andrew, Courtney, Laura, Veizer, Joelle, Kotkiewicz, Holland, Cho, Ting-Jan, Koutseva, Natalia, Rozen, Steve, Muzny, Donna M., Warren, Wesley C., Gibbs, Richard A., Wilson, Richard K., Page, David C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2012; Nature Publishing Group
• Subjects: 631/181/2474; 631/337/103; Animals; Artificial chromosomes; Biological and medical sciences; Chimpanzees; Chromosome mapping; Chromosomes; Chromosomes, Human, Y - genetics; Classical genetics, quantitative genetics, hybrids; Cloning; Confidence intervals; Conserved Sequence - genetics; Crossing Over, Genetic - genetics; Evolution, Molecular; Evolutionary genetics; Fundamental and applied biological sciences. Psychology; Gene Amplification - genetics; Gene Deletion; Genes; Genetic aspects; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Haplotypes; Human; Human chromosomes; Human genetics; Humanities and Social Sciences; Humans; Hybridization; In Situ Hybridization, Fluorescence; letter; Macaca mulatta - genetics; Male; Methods; Models, Genetic; Molecular Sequence Data; multidisciplinary; Pan troglodytes - genetics; Properties; Radiation Hybrid Mapping; Regression analysis; Rhesus monkey; Science; Science (multidisciplinary); Selection, Genetic - genetics; Stratigraphy; Time Factors; Y chromosome; Y Chromosome - genetics; United States; Human; Molecular evolution; Vertebrata; Mammalia; Sex chromosome; Primates; Simioidea; Macaca mulatta; X-Chromosome; Y-Chromosome; Comparative study

The male-specific region of rhesus macaque and human Y chromosome (MSY) are sequenced and compared to the human MSY, showing that during the last 25 million years MSY gene loss in the rhesus and human lineages was limited to the youngest stratum (stratum 5), whereas gene loss in the older strata cea...