Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers

• Published in: Psychopharmacology Vol. 232; no. 10; pp. 1793 - 1801
• Main Authors: Schmidt, Kristin, Cowen, Philip J., Harmer, Catherine J., Tzortzis, George, Errington, Steven, Burnet, Philip W. J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2015; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Animals; Anxiety; Biomedical and Life Sciences; Biomedicine; Dietary fiber; Dietary Supplements; Digestive system; Double-Blind Method; Emotions; Emotions - physiology; Female; Healthy Volunteers; Hormones; Humans; Hydrocortisone; Hydrocortisone - metabolism; Male; Microbiology; Middle Aged; Neurosciences; Oligosaccharides - administration & dosage; Original Investigation; Pharmacology/Toxicology; Photic Stimulation - methods; Physiological aspects; Prebiotics - administration & dosage; Probiotics; Psychiatry; Psychological aspects; Psychopharmacology; Rats; Saliva - metabolism; Wakefulness - physiology; Young Adult; United Kingdom; Gut microbiota; Emotional processing; Attention; Hypothalamic-pituitary-adrenal axis; Cortisol; Anxiety; Prebiotics

Rationale There is now compelling evidence for a link between enteric microbiota and brain function. The ingestion of probiotics modulates the processing of information that is strongly linked to anxiety and depression, and influences the neuroendocrine stress response. We have recently demonstrated...