Ketamine/xylazine and barbiturates modulate microglial morphology and motility differently in a mouse model

• Published in: PloS one Vol. 15; no. 8; p. e0236594
• Main Authors: Hristovska, Ines, Verdonk, Franck, Comte, Jean-Christophe, Tsai, Eileen S, Desestret, Virginie, Honnorat, Jérôme, Chrétien, Fabrice, Pascual, Olivier
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 06.08.2020; Public Library of Science (PLoS)
• Subjects: Anesthesia; Anesthesiology; Anesthetics; Barbiturates; Bernard, Claude (1813-1878); Biology and Life Sciences; Brain; Brain research; Complexity; Cytology; Cytoplasm; Dynamic tests; EEG; Electroencephalography; Homeostasis; Immune system; Ketamine; Life Sciences; Medicine; Medicine and Health Sciences; Microglia; Microglial cells; Morphology; Motility; Neural networks; Neurobiology; Neuroimaging; Neurons and Cognition; Neurotoxicity; Pain; Parenchyma; Pentobarbital; Pharmaceutical sciences; Pharmacology; Physiological aspects; Physiology; Reduction; Research and Analysis Methods; Software; Surgery; Thiopental; Xylazine; France; United States > US; California

Microglia, the resident immune cells of the brain, are highly ramified and motile and their morphology is strongly linked to their function. Microglia constantly monitor the brain parenchyma and are crucial for maintaining brain homeostasis and fine-tuning neuronal networks. Besides affecting neuron...