Consensus and variations in cell line specificity among human metapneumovirus strains

• Published in: PloS one Vol. 14; no. 4; p. e0215822
• Main Authors: Nao, Naganori, Sato, Ko, Yamagishi, Junya, Tahara, Maino, Nakatsu, Yuichiro, Seki, Fumio, Katoh, Hiroshi, Ohnuma, Aiko, Shirogane, Yuta, Hayashi, Masahiro, Suzuki, Tamio, Kikuta, Hideaki, Nishimura, Hidekazu, Takeda, Makoto
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.04.2019; Public Library of Science (PLoS)
• Subjects: A549 Cells; Analysis; Cell Line - virology; Cell lines; Cytopathogenic Effect, Viral - genetics; Fluorescence; Genes; Genetic aspects; Genomes; Genomics; Genotypes; Green Fluorescent Proteins - genetics; HEK293 Cells; HeLa Cells; Humans; Infection; Lung diseases; Metapneumovirus - genetics; Metapneumovirus - growth & development; Metapneumovirus - pathogenicity; Novels; Paramyxoviruses; Physiological aspects; Respiratory tract infections; Respiratory Tract Infections - genetics; Respiratory Tract Infections - prevention & control; Respiratory Tract Infections - virology; Risk factors

Human metapneumovirus (HMPV) has been a notable etiological agent of acute respiratory infection in humans, but it was not discovered until 2001, because HMPV replicates only in a limited number of cell lines and the cytopathic effect (CPE) is often mild. To promote the study of HMPV, several groups...