Injury markers predict time to dementia in subjects with MCI and amyloid pathology

• Published in: Neurology Vol. 79; no. 17; p. 1809
• Main Authors: van Rossum, Ineke A, Vos, Stephanie J B, Burns, Leah, Knol, Dirk L, Scheltens, Philip, Soininen, Hilkka, Wahlund, Lars-Olof, Hampel, Harald, Tsolaki, Magda, Minthon, Lennart, L'italien, Gilbert, van der Flier, Wiesje M, Teunissen, Charlotte E, Blennow, Kaj, Barkhof, Frederik, Rueckert, Daniel, Wolz, Robin, Verhey, Frans, Visser, Pieter Jelle
• Format: Journal Article
• Language: English
• Published: United States 23.10.2012
• Subjects: Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; Apolipoproteins E - genetics; Biomarkers - cerebrospinal fluid; Cognitive Dysfunction - cerebrospinal fluid; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - pathology; Cohort Studies; Disease Progression; Female; Hippocampus - pathology; Humans; Male; Multicenter Studies as Topic; Neuropsychological Tests; Predictive Value of Tests; Psychiatric Status Rating Scales; tau Proteins - cerebrospinal fluid; Time Factors

Alzheimer disease (AD) can now be diagnosed in subjects with mild cognitive impairment (MCI) using biomarkers. However, little is known about the rate of decline in those subjects. In this cohort study, we aimed to assess the conversion rate to dementia and identify prognostic markers in subjects wi...