GWAS for executive function and processing speed suggests involvement of the CADM2 gene

• Published in: Molecular psychiatry Vol. 21; no. 2; pp. 189 - 197
• Main Authors: Ibrahim-Verbaas, C A, Bressler, J, Schuur, M, Davies, G, Trompet, S, Smith, J A, Liu, Y, Vitart, V, Petrovic, K, Polasek, O, Zgaga, L, Fawns-Ritchie, C, Hoffmann, P, Karjalainen, J, Lahti, J, Llewellyn, D J, Schmidt, C O, Mather, K A, Chouraki, V, Resnick, S M, Rose, L M, Oldmeadow, C, Stewart, M, deJager, P L, Harris, T B, Liewald, D C, Amin, N, Coker, L H, Stegle, O, Lopez, O L, Teumer, A, Ford, I, Karbalai, N, Becker, J T, Jonsdottir, M K, Au, R, Fehrmann, R S N, Herms, S, Nalls, M, Yaffe, K, Lohman, K, van Swieten, J C, Kardia, S L R, Knopman, D S, Meeks, W M, Heiss, G, Holliday, E G, Tanaka, T, Stott, D J, Wang, J, Ridker, P, Pattie, A, Starr, J M, Hocking, L J, Armstrong, N J, McLachlan, S, Shulman, J M, Eiriksdottir, G, Scott, R J, Kochan, N A, Palotie, A, Hsieh, Y-C, Penman, A, Gottesman, R F, Yu, L, Beiser, A, Garcia, M, Rotter, J I, Slagboom, P E, Westendorp, R G J, Buckley, B M, Wolf, P A, Uitterlinden, A G, Grabe, H J, Bandinelli, S, Chasman, D I, Grodstein, F, Räikkönen, K, Porteous, D J, Price, J F, Sachdev, P S, Ferrucci, L, Attia, J R, Rudan, I, Hayward, C, Wright, A F, Wilson, J F, Cichon, S, Schmidt, H, Ding, J, de Craen, A J M, Fornage, M, Bennett, D A, Deary, I J, Ikram, M A, Launer, L J, Fitzpatrick, A L, Seshadri, S, van Duijn, C M, Mosley, T H
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2016; Nature Publishing Group
• Subjects: 45/43; 631/208; Aged; Aged, 80 and over; Aging; Behavioral Sciences; Biological Psychology; Cell adhesion & migration; Cell adhesion molecules; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - physiology; Cognition - physiology; Cognitive ability; Cohort Studies; Cortex (cingulate); Dementia; Dementia disorders; Diagnosis; Epidemiology; Executive function; Executive Function - physiology; Female; GABA; gamma-Aminobutyric Acid; Genetic aspects; Genetic Association Studies; Genetic diversity; Genetic Variation - genetics; Genome-wide association studies; Genome-Wide Association Study; Genomics; Humans; Information processing; Introns; Male; Measuring techniques; Medicine; Medicine & Public Health; Middle Aged; Neuropsychological Tests; Neurosciences; original-article; Pharmacotherapy; Physiological aspects; Polymorphism, Single Nucleotide; Processing speed; Psychiatry; Psychology; Replication; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Systematic review; Transcription; White People - genetics; γ-Aminobutyric acid; United States

To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Resea...