An obligatory role for neurotensin in high-fat-diet-induced obesity

• Published in: Nature (London) Vol. 533; no. 7603; pp. 411 - 415
• Main Authors: Li, Jing, Song, Jun, Zaytseva, Yekaterina Y., Liu, Yajuan, Rychahou, Piotr, Jiang, Kai, Starr, Marlene E., Kim, Ji Tae, Harris, Jennifer W., Yiannikouris, Frederique B., Katz, Wendy S., Nilsson, Peter M., Orho-Melander, Marju, Chen, Jing, Zhu, Haining, Fahrenholz, Timothy, Higashi, Richard M., Gao, Tianyan, Morris, Andrew J., Cassis, Lisa A., Fan, Teresa W. -M., Weiss, Heidi L., Dobner, Paul R., Melander, Olle, Jia, Jianhang, Evers, B. Mark
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.05.2016; Nature Publishing Group
• Subjects: 14/1; 14/19; 14/34; 14/63; 38; 38/1; 38/109; 38/22; 38/77; 38/89; 38/90; 59; 59/57; 64; 64/24; 64/60; 692/163/2743/2037; 692/163/2743/393; 82; 82/29; 82/51; 82/80; 82/83; 96; Adaptor Proteins, Vesicular Transport - metabolism; AMP-Activated Protein Kinases - metabolism; Animals; Cell Line; Clinical Medicine; Diet, High-Fat - adverse effects; Disease Models, Animal; Drosophila melanogaster - cytology; Drosophila melanogaster - enzymology; Drosophila melanogaster - metabolism; Endocrinology and Diabetes; Endokrinologi och diabetes; Enteroendocrine Cells - metabolism; Enzyme Activation; Fat Body - metabolism; Fatty Acids - metabolism; Fatty Liver - metabolism; Fatty Liver - prevention & control; Female; Health aspects; Humanities and Social Sciences; Humans; Insulin Resistance - physiology; Intestinal Mucosa - metabolism; Intestines - cytology; Ketogenic diet; Klinisk medicin; letter; Lipid Metabolism; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Mice; Middle Aged; multidisciplinary; Neurotensin; Neurotensin - blood; Neurotensin - deficiency; Neurotensin - genetics; Neurotensin - metabolism; Obesity; Obesity - blood; Obesity - chemically induced; Obesity - metabolism; Obesity - prevention & control; Physiological aspects; Protein Precursors - blood; Protein Precursors - metabolism; Science

Neurotensin, a peptide expressed in the enteroendocrine cells of the small intestine that is released upon fat ingestion, is shown to increase fatty acid absorption, with neurotensin-deficient mice being protected from obesity induced by a high-fat diet. Neurotensin is a factor in obesity Neurotensi...