Improved Survival and Neurological Outcomes after Cardiopulmonary Resuscitation in Toll-like Receptor 4-mutant Mice

• Published in: Chinese medical journal Vol. 128; no. 19; pp. 2646 - 2651
• Main Authors: Xu, Li, Zhang, Qing, Zhang, Qing-Song, Li, Qian, Han, Ji-Yuan, Sun, Peng
• Format: Journal Article
• Language: English
• Published: China Medknow Publications Pvt Ltd 05.10.2015; Medknow Publications and Media Pvt. Ltd; Lippincott Williams & Wilkins Ovid Technologies; Department of Emergency,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China%Department of Anesthesia,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China%Department of Urology,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China%Department of Emergency,Wuhan First Hospital,Wuhan,Hubei 430022,China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Animals; Anxiety; Blotting, Western; Brain - immunology; Brain - metabolism; Cardiac arrest; Cardiac Arrest; Cardiopulmonary Resuscitation; Cerebral Injury; Toll-like Receptor 4; Cardiopulmonary resuscitation; Cardiopulmonary Resuscitation - methods; Care and treatment; Catheters; CPR; Cytokines; Health aspects; Heart Arrest - genetics; Heart Arrest - metabolism; Heart Arrest - therapy; ICAM-1; Inflammation; Intercellular Adhesion Molecule-1 - metabolism; Ischemia; Male; Mice; Mutation; Original; Patient outcomes; Peroxidase - metabolism; Potassium; Rodents; Science; Signal transduction; Social interaction; TLR4; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - metabolism; Toll样受体4; Traumatic brain injury; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Ventilation; 心肺复苏; 生存率; 突变小鼠; 缺血/再灌注损伤; 酶联免疫吸附试验; 预后; China; Cardiac Arrest; Cardiopulmonary Resuscitation; Cerebral Injury; Toll-like Receptor 4

Background：Toll-like receptor 4 （TLR4） is a crucial receptor in the innate immune system and noninfectious immune responses.It has been reported that TLR4 participates in the pathological course of ischemia/reperfusion （I/R） injury.However,the role of TLR4 in the process of I/R injury after cardiac...