Limited Clinical Utility of a Genetic Risk Score for the Prediction of Fracture Risk in Elderly Subjects

• Published in: Journal of bone and mineral research Vol. 30; no. 1; pp. 184 - 194
• Main Authors: Eriksson, Joel, Evans, Daniel S, Nielson, Carrie M, Shen, Jian, Srikanth, Priya, Hochberg, Marc, McWeeney, Shannon, Cawthon, Peggy M, Wilmot, Beth, Zmuda, Joseph, Tranah, Greg, Mirel, Daniel B, Challa, Sashi, Mooney, Michael, Crenshaw, Andrew, Karlsson, Magnus, Mellström, Dan, Vandenput, Liesbeth, Orwoll, Eric, Ohlsson, Claes
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.01.2015
• Subjects: Aged; Aged, 80 and over; ASSESSMENT; Bone Density - genetics; Clinical Medicine; DXA; Endocrinology and Diabetes; Endokrinologi och diabetes; Female; FRACTURE RISK; FRACTURE RISK ASSESSMENT; Fractures, Bone - epidemiology; Fractures, Bone - genetics; GENERAL POPULATION STUDIES; HUMAN ASSOCIATION STUDIES; Humans; Klinisk medicin; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Models, Genetic; Orthopaedics; Orthopedics; Ortopedi; OSTEOPOROSIS; Osteoporosis - epidemiology; Osteoporosis - genetics; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prospective Studies; Risk Factors; DXA; FRACTURE RISK ASSESSMENT; HUMAN ASSOCIATION STUDIES; GENERAL POPULATION STUDIES; OSTEOPOROSIS

ABSTRACT It is important to identify the patients at highest risk of fractures. A recent large‐scale meta‐analysis identified 63 autosomal single‐nucleotide polymorphisms (SNPs) associated with bone mineral density (BMD), of which 16 were also associated with fracture risk. Based on these findings,...