Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing - Shuhendler, Adam J; Pu, Kanyi; Cui, Lina; Uetrecht, Jack P; Rao, Jianghong (Nature biotechnology, 2014)
Keywords: 59/5; 631/154/1438; 639/301/357/354; 639/925/350/59; Acetaminophen - toxicity; Agriculture; Animals; Bioinformatics; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Chemical and Drug Induced Liver Injury - metabolism; Chemiluminescence; Deoxyribonucleic acid; DNA; Drugs; Energy transfer; Female; Fluorescence; Fluorescence Resonance Energy Transfer - methods; Health aspects; Hepatotoxicity; Isoniazid - toxicity; Life Sciences; Liver; Liver - chemistry; Liver - drug effects; Methods; Mice; Mice, Nude; Models, Chemical; Nanoparticles; Nanotechnology; Nitrogen; Optical Imaging - methods; Oxidative stress; Oxidative Stress - drug effects; Physiological aspects; Polymers; Reactive Nitrogen Species - analysis; Reactive Oxygen Species - analysis; Real time; Remediation; Resonance; Tests; Toxicity; Toxicity testing; Toxicity Tests; Whole Body Imaging