Microbial Factor-Mediated Development in a Host-Bacterial Mutualism

• Published in: Science (American Association for the Advancement of Science) Vol. 306; no. 5699; pp. 1186 - 1188
• Main Authors: Koropatnick, Tanya A., Engle, Jacquelyn T., Apicella, Michael A., Stabb, Eric V., Goldman, William E., McFall-Ngai, Margaret J.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 12.11.2004; The American Association for the Advancement of Science
• Subjects: Aliivibrio fischeri - growth & development; Aliivibrio fischeri - metabolism; Aliivibrio fischeri - physiology; Anatomy; Animals; Apoptosis; Bacteria; Bacterial Toxins - metabolism; Bacterial Toxins - pharmacology; Bacteriology; Biological and medical sciences; Chromatography, High Pressure Liquid; Crypts; Cytotoxins - metabolism; Cytotoxins - pharmacology; Decapodiformes - cytology; Decapodiformes - growth & development; Decapodiformes - microbiology; Epithelial cells; Epithelial Cells - cytology; Epithelial Cells - physiology; Epithelium - microbiology; Epithelium - physiology; Euprymna scolopes; Fractions; Fundamental and applied biological sciences. Psychology; Hemocytes; Hemocytes - physiology; Land Settlement; Lipopolysaccharides - metabolism; Marine; Microbiology; Molecules; Mollusks; Morphogenesis; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains; Peptidoglycan - chemistry; Peptidoglycan - metabolism; Sexually Transmitted Diseases; Sinuses; Symbionts; Symbiosis; Vibrio fischeri; Whooping cough; Cephalopoda; Peptidoglycan; Toxin; Animal microorganism relation; Vibrio fischeri; Bacteria; Vibrionaceae; Invertebrata; Mollusca; Mutualism

Tracheal cytotoxin (TCT), a fragment of the bacterial surface molecule peptidoglycan (PGN), is the factor responsible for the extensive tissue damage characteristic of whooping cough and gonorrhea infections. Here, we report that Vibrio fischeri also releases TCT, which acts in synergy with lipopoly...