Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

• Published in: Nature (London) Vol. 466; no. 7308; pp. 829 - 834
• Main Authors: Méndez-Ferrer, Simón, Michurina, Tatyana V., Ferraro, Francesca, Mazloom, Amin R., MacArthur, Ben D., Lira, Sergio A., Scadden, David T., Ma’ayan, Avi, Enikolopov, Grigori N., Frenette, Paul S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.08.2010; Nature Publishing Group
• Subjects: 631/136/142; 631/136/232/1473/1542; 631/136/532/2074; 631/250/1620/1342; Animals; Biological and medical sciences; Bone marrow; Bone marrow cells; Cell Differentiation - drug effects; Cell differentiation, maturation, development, hematopoiesis; Cell Division; Cell Lineage - drug effects; Cell Movement; Cell physiology; Cells, Cultured; Chemokine CXCL12 - metabolism; Chondrocytes - cytology; Chondrocytes - drug effects; Fibers; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation - genetics; Genetic aspects; Granulocyte Colony-Stimulating Factor - pharmacology; Hematopoietic stem cells; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - drug effects; Hematopoietic Stem Cells - metabolism; Humanities and Social Sciences; Intermediate Filament Proteins - metabolism; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - drug effects; Mesenchymal Stem Cells - metabolism; Mice; Mice, Transgenic; Molecular and cellular biology; multidisciplinary; Multipotent Stem Cells - cytology; Multipotent Stem Cells - drug effects; Multipotent Stem Cells - metabolism; Nerve Tissue Proteins - metabolism; Nestin; Osteoblasts; Osteoblasts - cytology; Osteoblasts - drug effects; Osteoblasts - metabolism; Parathyroid Hormone - pharmacology; Physiological aspects; Proteins; Rodents; Science; Science (multidisciplinary); Stem Cell Niche - cytology; Stem Cell Niche - drug effects; Stem Cell Niche - metabolism; Stem cells; Stromal Cells - cytology; Stromal Cells - drug effects; Stromal Cells - metabolism; Studies; Sympathetic Nervous System - physiology; United States; United Kingdom; Bone marrow; Mesenchyma; Niche; Hematopoiesis; Stem cell

The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial and perivascular cells. Here we demonstrate that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC...