The presence of a single-nucleotide polymorphism in the BDNF gene affects the rate of locomotor adaptation after stroke

• Published in: Experimental brain research Vol. 234; no. 2; pp. 341 - 351
• Main Authors: Helm, Erin E., Tyrell, Christine M., Pohlig, Ryan T., Brady, Lucas D., Reisman, Darcy S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2016; Springer; Springer Nature B.V
• Subjects: Adaptation; Adaptation, Physiological - genetics; Aged; Biomedical and Life Sciences; Biomedicine; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Exercise Test - methods; Female; Fitness equipment; Genetic aspects; Growth factors; Humans; Male; Middle Aged; Motor Activity - genetics; Neurology; Neurosciences; Patient outcomes; Physical therapy; Physiological aspects; Polymorphism; Polymorphism, Single Nucleotide - genetics; Research Article; Single nucleotide polymorphisms; Stroke; Stroke (Disease); Stroke - complications; Stroke - diagnosis; Stroke - genetics; United States; United States > US; Val66Met polymorphism; Split-belt treadmill; Locomotor adaptation; Brain-derived neurotrophic factor; Chronic stroke

Induction of neural plasticity through motor learning has been demonstrated in animals and humans. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of growth factors, is thought to play an integral role in modulation of central nervous system plasticity during learning a...