The Lifespan and Turnover of Microglia in the Human Brain

• Published in: Cell reports (Cambridge) Vol. 20; no. 4; pp. 779 - 784
• Main Authors: Réu, Pedro, Khosravi, Azadeh, Bernard, Samuel, Mold, Jeff E., Salehpour, Mehran, Alkass, Kanar, Perl, Shira, Tisdale, John, Possnert, Göran, Druid, Henrik, Frisén, Jonas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.07.2017; Cell Press; Elsevier
• Subjects: Adolescent; Adult; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology; Brain - cytology; Brain - metabolism; Brain - physiology; Cell Division - genetics; Cell Division - physiology; Cell Proliferation - genetics; Cell Proliferation - physiology; Cell turnover; Dynamical Systems; human; human brain; Humans; Ion Physics; Jonfysik; Mathematics; microglia; Microglia - cytology; Microglia - metabolism; Microglia - physiology; proliferation; regeneration; renewal; Stem Cells - cytology; Stem Cells - metabolism; Stem Cells - physiology; turnover; proliferation; renewal; microglia; human; turnover

The hematopoietic system seeds the CNS with microglial progenitor cells during the fetal period, but the subsequent cell generation dynamics and maintenance of this population have been poorly understood. We report that microglia, unlike most other hematopoietic lineages, renew slowly at a median ra...