Epidemiological and genetic analysis of a 2014 outbreak of hepatitis A in Japan

• Published in: Vaccine Vol. 33; no. 45; pp. 6029 - 6036
• Main Authors: Ishii, Koji, Kiyohara, Tomoko, Yoshizaki, Sayaka, Kawabata, Kunio, Kanayama, Atsuhiro, Yahata, Yuichiro, Takahashi, Takuri, Kinoshita, Hitomi, Saitou, Takehito, Sunagawa, Tomimasa, Oishi, Kazunori, Uema, Masashi, Noda, Mamoru, Wakita, Takaji
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 09.11.2015; Elsevier Limited
• Subjects: Adult; Aged; algorithms; Allergy and Immunology; Base Sequence; Blood - virology; Collaboration; disease incidence; disease outbreaks; Disease Outbreaks - statistics & numerical data; Epidemiology; Feces; Feces - virology; Female; Genomes; Genotype; Genotype & phenotype; genotyping; Health surveillance; Hepatitis; hepatitis A; Hepatitis A - epidemiology; Hepatitis A - transmission; Hepatitis A - virology; Hepatitis A virus; Hepatitis A virus - classification; Hepatitis A virus - genetics; Hepatovirus A; Humans; Industrialized nations; Infections; Infectious diseases; Japan; Japan - epidemiology; Male; Middle Aged; nucleotide sequences; Outbreak; Outbreaks; patients; Phylogenetic analysis; Phylogenetics; Phylogeny; Polymerase chain reaction; Public health; RNA, Viral - genetics; Shellfish; Trees; vaccines; Viral Structural Proteins - genetics; Japan; Phylogenetic analysis; Genotype; Hepatitis A virus; Outbreak

•Most of a hepatitis A outbreak reported in spring of 2014 in Japan was caused by a single strain distributed simultaneously throughout Japan. Hepatitis A virus (HAV) is one of the most common causes of feces-transmitted acute hepatitis worldwide. In Japan, most of HAV infections have been sporadic...