Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

• Published in: PLoS pathogens Vol. 17; no. 9; p. e1009878
• Main Authors: Severa, Martina, Diotti, Roberta A., Etna, Marilena P., Rizzo, Fabiana, Fiore, Stefano, Ricci, Daniela, Iannetta, Marco, Sinigaglia, Alessandro, Lodi, Alessandra, Mancini, Nicasio, Criscuolo, Elena, Clementi, Massimo, Andreoni, Massimo, Balducci, Stefano, Barzon, Luisa, Stefanelli, Paola, Clementi, Nicola, Coccia, Eliana M.
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 02.09.2021; Public Library of Science (PLoS)
• Subjects: Antiviral agents; Antiviral drugs; Asymptomatic; Biology and life sciences; Carrier state (Communicable diseases); Cell culture; Cell interaction; Cell surface; Chemokines; Coronaviruses; COVID-19; Cytokine storm; Cytokines; Dendritic cells; Development and progression; Disease; Epithelial cells; Epithelium; Experiments; Gene expression; Health aspects; Immune response; Immune system; Infections; Inflammation; Interferon; Ligands; Medicine and health sciences; Movement disorders; Neuropilin; PD-L1 protein; Peripheral blood mononuclear cells; Phenotypes; Pneumonia; Replication; Respiratory diseases; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; TLR7 protein; Toll-like receptors; Very Low Frequencies; Viral diseases; Viral infections; Viruses; Italy

SARS-CoV-2 fine-tunes the interferon (IFN)-induced antiviral responses, which play a key role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill patients show an impaired type I IFN response accompanied by elevated inflammatory cytokine and chemokine levels, respon...