CIS is a potent checkpoint in NK cell–mediated tumor immunity

• Published in: Nature immunology Vol. 17; no. 7; pp. 816 - 824
• Main Authors: Delconte, Rebecca B, Kolesnik, Tatiana B, Dagley, Laura F, Rautela, Jai, Shi, Wei, Putz, Eva M, Stannard, Kimberley, Zhang, Jian-Guo, Teh, Charis, Firth, Matt, Ushiki, Takashi, Andoniou, Christopher E, Degli-Esposti, Mariapia A, Sharp, Phillip P, Sanvitale, Caroline E, Infusini, Giuseppe, Liau, Nicholas P D, Linossi, Edmond M, Burns, Christopher J, Carotta, Sebastian, Gray, Daniel H D, Seillet, Cyril, Hutchinson, Dana S, Belz, Gabrielle T, Webb, Andrew I, Alexander, Warren S, Li, Shawn S, Bullock, Alex N, Babon, Jeffery J, Smyth, Mark J, Nicholson, Sandra E, Huntington, Nicholas D
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2016; Nature Publishing Group
• Subjects: 13/21; 14/35; 631/250/2504/2506; 631/45/275; 692/699/67/580/1884; 82; 82/58; Animals; Biomedicine; Cancer; Cancer immunotherapy; Cancer metastasis; Carcinogenesis; Carcinoma in situ; Care and treatment; Cell proliferation; Cell Proliferation - genetics; Cellular signal transduction; Cytokines; Cytotoxicity; Cytotoxicity, Immunologic - genetics; Diagnosis; Dosage and administration; Enzymatic activity; Genetic aspects; Health aspects; Immunity; Immunologic Surveillance; Immunology; Immunotherapy; Immunotherapy - methods; Infectious Diseases; Interferon-gamma - metabolism; Interleukin 15; Interleukin-15 - metabolism; Janus kinase; Janus Kinase 1 - metabolism; Killer cells; Killer Cells, Natural - immunology; Kinases; Lymphocyte Activation - genetics; Melanoma; Melanoma, Experimental; Metastases; Metastasis; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Targeted Therapy; Natural killer cells; Neoplasms - immunology; Neoplasms - therapy; Prostate cancer; Proteasomes; Protein-tyrosine kinase; Signal Transduction - genetics; Suppressor of Cytokine Signaling Proteins - genetics; Suppressor of Cytokine Signaling Proteins - metabolism; Tumors; Tyrosine; γ-Interferon

IL-15-driven NK cells mediate anti-tumor immunity, but how IL-15 is negatively regulated remains unclear. Huntington and colleagues find that CIS, a member of the suppressor of cytokine signaling family, suppresses the response to IL-15 and, as a result, CIS-deficient mice are more resistant to canc...