In vitro immunomodulation for enhancing T cell–based diagnosis of Mycobacterium tuberculosis infection

• Published in: Diagnostic microbiology and infectious disease Vol. 83; no. 1; pp. 41 - 45
• Main Authors: Slater, Madeline, Tran, Minh-Chi, Platt, Lauren, Luu, Lien T., Phan, Ha T., Pham, Phuong T., Do, Tam B., Nguyen, Hanh T., Gaur, Rajiv L., Parsonnet, Julie, Cattamanchi, Adithya, Luo, Robert, Nahid, Payam, Banaei, Niaz
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2015
• Subjects: Adult; Aged; Female; Health Personnel; Humans; Immunologic Factors - metabolism; Infectious Disease; Interferon gamma release assays; Interferon-gamma Release Tests - methods; Internal Medicine; Lipopolysaccharides - metabolism; Male; Middle Aged; Mycobacterium tuberculosis; Mycobacterium tuberculosis - immunology; Pathogen associated molecular patterns; Poly I-C - metabolism; Prospective Studies; Quantiferon; Sensitivity and Specificity; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; Tuberculosis; Tuberculosis - diagnosis; United States; Vietnam; Interferon gamma release assays; Tuberculosis; Quantiferon; Pathogen associated molecular patterns

Interferon-gamma release assays have limited sensitivity for detecting latent tuberculosis infection. In this study, we determine if the addition of immunomodulators to the QuantiFERON-TB Gold In-Tube (QFT-GIT) increased test sensitivity without compromising specificity. We prospectively compared QF...