Apoptosis of Lewis Lung Carcinoma Cells Induced by Microwave via p53 and Proapoptotic Proteins In vivo

• Published in: Chinese medical journal Vol. 130; no. 1; pp. 15 - 22
• Main Authors: Zhang, Kou-Dong, Tong, Lin-Rong, Wang, Shui-Ming, Peng, Rui-Yun, Huang, Hai-Dong, Dong, Yu-Chao, Zhang, Xing-Xing, Li, Qiang, Bai, Chong
• Format: Journal Article
• Language: English
• Published: China Wolters Kluwer India Pvt. Ltd 01.01.2017; Medknow Publications and Media Pvt. Ltd; Lippincott Williams & Wilkins Ovid Technologies; Department of Respiratory and Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China; Department of Respiratory Medicine, Yancheng First People's Hospital, Yancheng, Jiangsu 224000, China%Department of Respiratory Medicine, Chenggong Hospital, Xiamen University, Xiamen, Fujian 361000, China%Institute of Radiation Medicine, The Academy of Military Medical Sciences, Beijing 100850, China%Department of Respiratory and Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Animals; Apoptosis; Apoptosis - radiation effects; Apoptosis Regulatory Proteins - metabolism; Apoptosis; Lewis Lung Carcinoma Cells; Microwave Radiation; Non-small-cell Lung Cancer; bcl-2-Associated X Protein - metabolism; Body Temperature - radiation effects; Cancer therapies; Carcinoma, Lewis Lung - metabolism; Carcinoma, Lewis Lung - pathology; Carcinoma, Lewis Lung - therapy; Care and treatment; Caspase 3 - metabolism; Cell Division - radiation effects; Cell Line, Tumor; Chemotherapy; Critical care; Development and progression; DNA Nucleotidylexotransferase - metabolism; Drug dosages; Health aspects; Immunohistochemistry; Laboratory animals; Lung cancer; Male; Medical prognosis; Medicine; Mice; Mice, Inbred C57BL; Microwaves; Non-small cell lung cancer; Original; p53; Physiological aspects; Radiation therapy; Radiotherapy; Rodents; Tumor proteins; Tumor Suppressor Protein p53 - metabolism; Tumors; Western印迹法; 体内; 微波诱导; 微波辐射技术; 抗凋亡蛋白; 肿瘤细胞凋亡; 非小细胞肺癌; China; Microwave Radiation; Non-small-cell Lung Cancer; Lewis Lung Carcinoma Cells; Apoptosis

Background： Microwave therapy is a minimal invasive procedure and has been employed in clinical practice for the treatment of various types of cancers. However, its therapeutic application in non-small-cell lung cancer and the underlying mechanism remains to be investigated. This study aimed to inve...