Chondrocyte necrosis and apoptosis in impact damaged articular cartilage

• Published in: Journal of orthopaedic research Vol. 19; no. 4; pp. 703 - 711
• Main Authors: Chen, Chih-Tung, Burton-Wurster, Nancy, Borden, Caroline, Hueffer, Karsten, Bloom, Stephen E, Lust, George
• Format: Journal Article
• Language: English
• Published: Hoboken Elsevier Ltd 01.07.2001; Wiley Subscription Services, Inc., A Wiley Company; Blackwell Publishing Ltd
• Subjects: Animals; Apoptosis; Cartilage, Articular - injuries; Cartilage, Articular - pathology; Cell Nucleus - ultrastructure; Cell Survival; Cells, Cultured; Chondrocytes - pathology; Chondrocytes - ultrastructure; Dogs; In Situ Nick-End Labeling; Microscopy, Electron; Necrosis

A decrease in chondrocyte numbers is one characteristic of osteoarthritic cartilage. This decrease may be the result of apoptosis or other forms of cell death induced by mechanical damage. Furthermore, cell death may contribute to the structural and metabolic changes found in osteoarthritic cartilag...