An epistatic ratchet constrains the direction of glucocorticoid receptor evolution - Bridgham, Jamie T.; Ortlund, Eric A.; Thornton, Joseph W. (Nature (London), 2009)
Keywords: Animals; Biological and medical sciences; Biological evolution; Cellular proteins; Changes; CHO Cells; Cricetinae; Cricetulus; Crystallography; Crystallography, X-Ray; Epistasis, Genetic; Evolution, Molecular; Fundamental and applied biological sciences. Psychology; Gene mutations; Genetic aspects; Genetics of eukaryotes. Biological and molecular evolution; Genotype & phenotype; Hormone receptors; Hormones - metabolism; Humanities and Social Sciences; Hydrogen bonds; letter; Life history; Models, Biological; Models, Molecular; Molecular biophysics; multidisciplinary; Mutation; Mutation - genetics; Neurons; Physiological aspects; Protein Engineering; Proteins; Receptors, Glucocorticoid - chemistry; Receptors, Glucocorticoid - genetics; Receptors, Glucocorticoid - metabolism; Science; Science (multidisciplinary); Sequence Alignment; Structure in molecular biology; Substrate Specificity; Tridimensional structure; United States; Molecular evolution; Reversibility; Specificity; Vertebrata; Three dimensional structure; Glucocorticoid receptor