The Molecular Mechanism of Sirt1 Signaling Pathway in Brain Injury of Newborn Rats Exposed to Hyperoxia

• Published in: Biological & pharmaceutical bulletin Vol. 42; no. 11; pp. 1854 - 1860
• Main Authors: Kang, Lan, Dong, Wenbin, Ruan, Ying, Zhang, Rong, Wang, Xingyong
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.11.2019; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Animals; Animals, Newborn; Apoptosis; Body Weight; Brain - metabolism; Brain Injuries - metabolism; Brain Injuries - pathology; Brain injury; Deacetylation; DNA nucleotidylexotransferase; Gene expression; Hyperoxia; Hyperoxia - metabolism; mRNA; p53 Protein; Polymerase chain reaction; Rats, Sprague-Dawley; Reactive oxygen species; Reactive Oxygen Species - metabolism; Rodents; Signal transduction; Sirt1; SIRT1 protein; Sirtuin 1 - metabolism; Traumatic brain injury; Tumor Suppressor Protein p53 - metabolism; Water content; hyperoxia; brain injury; Sirt1

The aim of the study was to investigate the changes in the reactive oxygen species (ROS), Sirt1, p53 and acetylated p53 in brain tissue of newborn rats exposed to hyperoxia to clarify the role of Sirt1 signaling pathway in brain injury. Neonate rats were randomly divided into normoxic group and hype...