Endothelial-to-mesenchymal transition drives atherosclerosis progression

• Published in: The Journal of clinical investigation Vol. 125; no. 12; pp. 4514 - 4528
• Main Authors: Chen, Pei-Yu, Qin, Lingfeng, Baeyens, Nicolas, Li, Guangxin, Afolabi, Titilayo, Budatha, Madhusudhan, Tellides, George, Schwartz, Martin A., Simons, Michael
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.12.2015
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Animals; Apolipoproteins E - genetics; Apolipoproteins E - metabolism; Atherosclerosis; Biomechanics; Biomedical research; Collagen; Coronary Artery Disease - genetics; Coronary Artery Disease - metabolism; Coronary Artery Disease - pathology; Coronary vessels; Cytokines; Development and progression; Fibroblast growth factor receptors; Gene expression; Genetic aspects; Health aspects; Heart attacks; Human Umbilical Vein Endothelial Cells - metabolism; Human Umbilical Vein Endothelial Cells - pathology; Humans; Hypertension; Inflammation; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Knockout; Proteins; Receptor, Fibroblast Growth Factor, Type 1 - genetics; Receptor, Fibroblast Growth Factor, Type 1 - metabolism; Shear stress; Smooth muscle; Software; Studies; Transforming Growth Factor beta - genetics; Transforming Growth Factor beta - metabolism; Veins & arteries

The molecular mechanisms responsible for the development and progression of atherosclerotic lesions have not been fully established. Here, we investigated the role played by endothelial-to-mesenchymal transition (EndMT) and its key regulator FGF receptor 1 (FGFR1) in atherosclerosis. In cultured hum...