Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer

• Published in: The Journal of clinical investigation Vol. 126; no. 11; pp. 4157 - 4173
• Main Authors: Yin, Mingzhu, Li, Xia, Tan, Shu, Zhou, Huanjiao Jenny, Ji, Weidong, Bellone, Stefania, Xu, Xiaocao, Zhang, Haifeng, Santin, Alessandro D., Lou, Ge, Min, Wang
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.11.2016
• Subjects: Analysis; Animals; Biomedical research; Female; Gene expression; Heterografts; Humans; Intercellular Adhesion Molecule-1 - metabolism; Macrophage-1 Antigen - metabolism; Macrophages; Macrophages - metabolism; Macrophages - pathology; Medical prognosis; Metastasis; Mice; Mice, Nude; Mortality; Neoplasm Metastasis; Neoplasm Proteins - metabolism; Neoplasm Transplantation; Ovarian cancer; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Prognosis; Receptor, Epidermal Growth Factor - metabolism; Risk factors; Spheroids, Cellular - metabolism; Spheroids, Cellular - pathology; Studies; Vascular Endothelial Growth Factor A - metabolism; Vascular Endothelial Growth Factor Receptor-1 - metabolism

Tumor-associated macrophages (TAMs) can influence ovarian cancer growth, migration, and metastasis, but the detailed mechanisms underlying ovarian cancer metastasis remain unclear. Here, we have shown a strong correlation between TAM-associated spheroids and the clinical pathology of ovarian cancer....