Dissociable Patterns of Neural Activity During Response Inhibition in Depressed Adolescents With and Without Suicidal Behavior

• Published in: Journal of the American Academy of Child and Adolescent Psychiatry Vol. 50; no. 6; pp. 602 - 611.e3
• Main Authors: Pan, Lisa A., Batezati-Alves, Silvia C., Almeida, Jorge R.C., Segreti, AnnaMaria, Akkal, Dalila, Hassel, Stefanie, Lakdawala, Sara, Brent, David A., Phillips, Mary L.
• Format: Journal Article
• Language: English
• Published: Maryland Heights, MO Elsevier Inc 01.06.2011; Elsevier; Elsevier BV
• Subjects: adolescence; Adolescent; Adolescents; Adult and adolescent clinical studies; Anticonvulsants - therapeutic use; Antidepressive Agents - therapeutic use; Antipsychotic Agents - therapeutic use; Attention - physiology; Attention Control; Biological and medical sciences; Brain; Brain - physiopathology; Brain Hemisphere Functions; Brain Mapping; Cerebral Cortex - physiopathology; Child clinical studies; Child psychology; cingulate; Control Groups; Depression; Depression (Psychology); Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - physiopathology; Depressive Disorder, Major - psychology; Depressive personality disorders; Diagnostic Tests; Dominance, Cerebral - physiology; Female; Frontal Lobe - physiopathology; Gyrus Cinguli - physiopathology; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Inhibition; Inhibition, Psychological; Integrity; Magnetic Resonance Imaging; Male; Medical sciences; Mental depression; Mesencephalon - physiopathology; Mood disorders; Motor Reactions; Nerve Net - physiopathology; NMR; Nuclear magnetic resonance; Oxygen Consumption - physiology; Parietal Lobe - physiopathology; Pattern Recognition, Visual - physiology; Pediatrics; prefrontal cortex; Prefrontal Cortex - physiopathology; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychomotor Performance - physiology; Psychopathology. Psychiatry; Reference Values; Response inhibition; Suicidal behaviour; Suicidal Ideation; Suicide; Suicide, Attempted - psychology; Suicides & suicide attempts; Symptoms; Task Analysis; Teenagers; Temporal Lobe - physiopathology; adolescence; cingulate; prefrontal cortex; response inhibition; suicide; Human; Mood disorder; Central nervous system; Depression; Prefrontal cortex; Suicide; Encephalon; Suicide attempt; Cingulate cortex; Adolescent; Inhibition; Comparative study

Impaired attentional control and behavioral control are implicated in adult suicidal behavior. Little is known about the functional integrity of neural circuitry supporting these processes in suicidal behavior in adolescence. Functional magnetic resonance imaging was used in 15 adolescent suicide at...