Anchoring the T6SS to the cell wall: Crystal structure of the peptidoglycan binding domain of the TagL accessory protein

• Published in: PloS one Vol. 16; no. 7; p. e0254232
• Main Authors: Nguyen, Van Son, Spinelli, Silvia, Cascales, Éric, Roussel, Alain, Cambillau, Christian, Leone, Philippe
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 02.07.2021; Public Library of Science (PLoS)
• Subjects: Analysis; Bacteria; Binding sites; Biology and Life Sciences; Cell walls; Chromatography; Crystal structure; Crystallization; Crystals; Data collection; Domains; Gram-negative bacteria; Life Sciences; Medicine and Health Sciences; Peptidoglycans; Physical Sciences; Protein binding; Proteins; Structure; Virulence; Virulence factors; France; Molecular structure; Cell walls; Peptidoglycans; Outer membrane proteins; Sequence alignment; DNA cloning; Secretion systems; Crystal structure

The type VI secretion system (T6SS) is a widespread mechanism of protein delivery into target cells, present in more than a quarter of all sequenced Gram-negative bacteria. The T6SS constitutes an important virulence factor, as it is responsible for targeting effectors in both prokaryotic and eukary...