Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease - Tanaka, Motomasa; Ishizuka, Koko; Nekooki-Machida, Yoko; Endo, Ryo; Takashima, Noriko; Sasaki, Hideyuki; Komi, Yusuke; Gathercole, Amy; Huston, Elaine; Ishii, Kazuhiro; Hui, Kelvin Kai-Wan; Kurosawa, Masaru; et al. (The Journal of clinical investigation, 2017)
Keywords: Animals; Behavior; Biomedical research; Brain research; Care and treatment; Cellular proteins; Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism; Development and progression; Experiments; Female; Gene expression; Genetic aspects; Health aspects; HEK293 Cells; Humans; Huntingtin Protein - genetics; Huntingtin Protein - metabolism; Huntington Disease - enzymology; Huntington's disease; Huntingtons disease; Mice, Transgenic; Mutation; Nerve Tissue Proteins - metabolism; Pathology; Phosphodiesterases; Protein Aggregation, Pathological - enzymology; Proteins; Scientists; Studies