Endothelial ERK signaling controls lymphatic fate specification

• Published in: The Journal of clinical investigation Vol. 123; no. 3; pp. 1202 - 1215
• Main Authors: Deng, Yong, Atri, Deepak, Eichmann, Anne, Simons, Michael
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.03.2013
• Subjects: Animals; Aorta - pathology; Biomedical research; Body Patterning; Butadienes - pharmacology; Cells, Cultured; Cellular signal transduction; Development and progression; Edema; Endothelium, Lymphatic - embryology; Endothelium, Lymphatic - pathology; Extracellular signal-regulated kinases; Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors; Extracellular Signal-Regulated MAP Kinases - metabolism; Female; Gene Expression; Gene Expression Regulation, Developmental; Genetic aspects; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Human Umbilical Vein Endothelial Cells - metabolism; Human Umbilical Vein Endothelial Cells - physiology; Humans; Kinases; Lymphangiectasis - genetics; Lymphangiectasis - metabolism; Lymphangiectasis - pathology; Lymphangiogenesis; Lymphatic system; Male; MAP Kinase Signaling System; Mice; Mice, Transgenic; Mutation; Mutation, Missense; Nitriles - pharmacology; Noonan syndrome; Phosphorylation; Physiological aspects; Proto-Oncogene Proteins c-akt - metabolism; Proto-Oncogene Proteins c-raf - genetics; Proto-Oncogene Proteins c-raf - metabolism; SOXF Transcription Factors - genetics; SOXF Transcription Factors - metabolism; Transgenic animals; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Up-Regulation; Vascular Endothelial Growth Factor Receptor-3 - metabolism; Veins & arteries

Lymphatic vessels are thought to arise from PROX1-positive endothelial cells (ECs) in the cardinal vein in response to induction of SOX18 expression; however, the molecular event responsible for increased SOX18 expression has not been established. We generated mice with endothelial-specific, inducib...