Helminth-Induced Immune Regulation: Implications for Immune Responses to Tuberculosis

• Published in: PLoS pathogens Vol. 11; no. 1; p. e1004582
• Main Authors: Chatterjee, Soumya, Nutman, Thomas B.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2015; Public Library of Science (PLoS)
• Subjects: Adaptive Immunity - physiology; Age; Animals; Animals, Newborn; Antigen-Presenting Cells - physiology; Coinfection; Disease; Female; Health aspects; Helminthiasis - epidemiology; Helminthiasis - immunology; Helminthiasis - transmission; Helminths; Helminths - immunology; Host-parasite relationships; Humans; Identification and classification; Immune response; Immune system; Immunomodulation - physiology; Infant, Newborn; Infections; Lymphocytes; Mortality; Mycobacterium tuberculosis - immunology; Pearls; Physiological aspects; Pregnancy; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Parasitic - immunology; Studies; T-Lymphocytes - immunology; Tuberculosis; Tuberculosis - epidemiology; Tuberculosis - immunology; United States
• ISSN: 1553-7374; 1553-7366; 1553-7374
• DOI: 10.1371/journal.ppat.1004582

  [...]adult subjects in endemic areas with chronic helminth infection show impaired cellular responses that may alter the responses to Mtb antigens and possibly contribute to a higher incidence of active TB disease [12]. [...]subjects with latent TB and filarial coinfection have been shown to exhibit decreased toll-like receptor 2 (TLR2) and toll-like receptor 9 (TLR9) expression, which was reversed after successful antifilarial chemotherapy [30].\n Using the diagnostic tools available to these investigators, the rates of acquisition of parasitic infection by infants enrolled in this study were very low, suggesting that helminth-induced T cell priming at birth may have long-lasting consequences for immunologic memory.