Helminth-Induced Immune Regulation: Implications for Immune Responses to Tuberculosis
[...]adult subjects in endemic areas with chronic helminth infection show impaired cellular responses that may alter the responses to Mtb antigens and possibly contribute to a higher incidence of active TB disease [12]. [...]subjects with latent TB and filarial coinfection have been shown to exhib...
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| Published in | PLoS pathogens Vol. 11; no. 1; p. e1004582 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
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Public Library of Science
01.01.2015
Public Library of Science (PLoS) |
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| Abstract |
[...]adult subjects in endemic areas with chronic helminth infection show impaired cellular responses that may alter the responses to Mtb antigens and possibly contribute to a higher incidence of active TB disease [12]. [...]subjects with latent TB and filarial coinfection have been shown to exhibit decreased toll-like receptor 2 (TLR2) and toll-like receptor 9 (TLR9) expression, which was reversed after successful antifilarial chemotherapy [30].\n Using the diagnostic tools available to these investigators, the rates of acquisition of parasitic infection by infants enrolled in this study were very low, suggesting that helminth-induced T cell priming at birth may have long-lasting consequences for immunologic memory. |
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| AbstractList |
[...]adult subjects in endemic areas with chronic helminth infection show impaired cellular responses that may alter the responses to Mtb antigens and possibly contribute to a higher incidence of active TB disease [12]. [...]subjects with latent TB and filarial coinfection have been shown to exhibit decreased toll-like receptor 2 (TLR2) and toll-like receptor 9 (TLR9) expression, which was reversed after successful antifilarial chemotherapy [30].\n Using the diagnostic tools available to these investigators, the rates of acquisition of parasitic infection by infants enrolled in this study were very low, suggesting that helminth-induced T cell priming at birth may have long-lasting consequences for immunologic memory. |
| Audience | Academic |
| Author | Chatterjee, Soumya Nutman, Thomas B. |
| AuthorAffiliation | University of Wisconsin Medical School, UNITED STATES Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America |
| AuthorAffiliation_xml | – name: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America – name: University of Wisconsin Medical School, UNITED STATES |
| Author_xml | – sequence: 1 givenname: Soumya surname: Chatterjee fullname: Chatterjee, Soumya – sequence: 2 givenname: Thomas B. surname: Nutman fullname: Nutman, Thomas B. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25632943$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Adaptive Immunity - physiology Age Animals Animals, Newborn Antigen-Presenting Cells - physiology Coinfection Disease Female Health aspects Helminthiasis - epidemiology Helminthiasis - immunology Helminthiasis - transmission Helminths Helminths - immunology Host-parasite relationships Humans Identification and classification Immune response Immune system Immunomodulation - physiology Infant, Newborn Infections Lymphocytes Mortality Mycobacterium tuberculosis - immunology Pearls Physiological aspects Pregnancy Pregnancy Complications, Infectious - immunology Pregnancy Complications, Parasitic - immunology Studies T-Lymphocytes - immunology Tuberculosis Tuberculosis - epidemiology Tuberculosis - immunology |
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| Title | Helminth-Induced Immune Regulation: Implications for Immune Responses to Tuberculosis |
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