Migrant memory B cells secrete luminal antibody in the vagina

• Published in: Nature (London) Vol. 571; no. 7763; pp. 122 - 126
• Main Authors: Oh, Ji Eun, Iijima, Norifumi, Song, Eric, Lu, Peiwen, Klein, Jonathan, Jiang, Ruoyi, Kleinstein, Steven H., Iwasaki, Akiko
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2019; Nature Publishing Group
• Subjects: 13; 13/1; 13/105; 13/31; 13/51; 14; 14/19; 38; 38/89; 631/250/2152/2153/1291; 631/250/590; Animals; Antibodies; Antibodies - immunology; Antibody Formation - immunology; B cells; B-Lymphocytes - cytology; B-Lymphocytes - immunology; Bone marrow; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; Cell adhesion & migration; Cell Movement - immunology; Chemokines; CXCL10 protein; CXCR3 protein; Dendritic cells; Female; Females; Herpes simplex; Herpes Simplex - immunology; Herpes Simplex - virology; Herpes viruses; Herpesvirus 2, Human - immunology; Human papillomavirus; Humanities and Social Sciences; Immunization; Immunoglobulin A; Immunoglobulin A - immunology; Immunoglobulin G; Immunoglobulin G - immunology; Immunoglobulin receptors; Immunoglobulins; Immunologic Memory - immunology; Immunological memory; Infections; Influenza; Interferon; Interferon-gamma - immunology; Intestine; Lamina propria; Letter; Lymphocytes; Lymphocytes B; Lymphocytes T; Memory cells; Mice; Mice, Inbred C57BL; Mucosa; multidisciplinary; Physiological aspects; Plasma cells; Receptors; Receptors, CXCR3 - immunology; Reproductive system; Science; Science (multidisciplinary); Vagina; Vagina - cytology; Vagina - immunology; Vagina - virology; Vaginosis; Viral antibodies; Viruses; United States; United States > US

Antibodies secreted into mucosal barriers serve to protect the host from a variety of pathogens, and are the basis for successful vaccines 1 . In type I mucosa (such as the intestinal tract), dimeric IgA secreted by local plasma cells is transported through polymeric immunoglobulin receptors 2 and m...