Heritability and genomics of gene expression in peripheral blood

• Published in: Nature genetics Vol. 46; no. 5; pp. 430 - 437
• Main Authors: Wright, Fred A, Sullivan, Patrick F, Brooks, Andrew I, Zou, Fei, Sun, Wei, Xia, Kai, Madar, Vered, Jansen, Rick, Chung, Wonil, Zhou, Yi-Hui, Abdellaoui, Abdel, Batista, Sandra, Butler, Casey, Chen, Guanhua, Chen, Ting-Huei, D'Ambrosio, David, Gallins, Paul, Ha, Min Jin, Hottenga, Jouke Jan, Huang, Shunping, Kattenberg, Mathijs, Kochar, Jaspreet, Middeldorp, Christel M, Qu, Ani, Shabalin, Andrey, Tischfield, Jay, Todd, Laura, Tzeng, Jung-Ying, van Grootheest, Gerard, Vink, Jacqueline M, Wang, Qi, Wang, Wei, Wang, Weibo, Willemsen, Gonneke, Smit, Johannes H, de Geus, Eco J, Yin, Zhaoyu, Penninx, Brenda W J H, Boomsma, Dorret I
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.05.2014; Nature Publishing Group
• Subjects: 38; 38/43; 631/208/199; 631/208/205/2138; Agriculture; Animal Genetics and Genomics; Biomedicine; Blood; Blood - metabolism; Cancer Research; Gene expression; Gene Expression Profiling; Gene Expression Regulation - genetics; Gene Function; Gene mapping; Genetic aspects; Genetic research; Genomics; Genotype; Heritability; Human Genetics; Humans; Identification and classification; Inheritance Patterns - genetics; Likelihood Functions; Netherlands; Polymorphism, Single Nucleotide - genetics; Quality control; Quantitative Trait Loci - genetics; Studies; Twins; Netherlands

Fred Wright, Patrick Sullivan and colleagues present the results of a large expression QTL study of peripheral blood using a classic twin design with follow-up replication in independent samples. Their results enable a more precise estimate of the heritability of gene expression and provide a useful...