Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies

• Published in: Biological & pharmaceutical bulletin Vol. 41; no. 5; pp. 697 - 706
• Main Authors: Ishizaki, Yuma, Furihata, Tomomi, Oyama, Yusuke, Ohura, Kayoko, Imai, Teruko, Hosokawa, Masakiyo, Akita, Hidetaka, Chiba, Kan
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.05.2018; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Caco-2 cell; Carboxylesterase; Colon; Drug development; Drug metabolism; drug permeability; Enterocytes; Gene expression; Hydrolase; mRNA; Permeability; prodrug; Serine; Serine hydrolase; Small intestine; prodrug; carboxylesterase; small intestine; drug permeability; Caco-2 cell

Carboxylesterase 2 (CES2), which is a member of the serine hydrolase superfamily, is primarily expressed in the human small intestine, where it plays an important role in the metabolism of ester-containing drugs. Therefore, to facilitate continued progress in ester-containing drug development, it is...