Vitamin K2 Suppresses Proliferation and Inflammatory Cytokine Production in Mitogen-Activated Lymphocytes of Atopic Dermatitis Patients through the Inhibition of Mitogen-Activated Protein Kinases

• Published in: Biological & pharmaceutical bulletin Vol. 44; no. 1; pp. 7 - 17
• Main Authors: Suzuki, Shunsuke, Miura, Taro, Zhang, Meiyu, Chiyotanda, Masako, Sugiyama, Kentaro, Kawashima, Hisashi, Tanaka, Sachiko, Hirano, Toshihiko
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.01.2021; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Atopic dermatitis; c-Jun protein; Cell culture; Concanavalin A; cytokine; Cytokines; Dermatitis; Eczema; Enzyme-linked immunosorbent assay; Extracellular signal-regulated kinase; Helper cells; Inflammation; Interleukin 10; Interleukin 2; JNK protein; Kinases; Leukocytes (mononuclear); Lymphocytes T; MAP kinase; Menaquinones; mitogen-activated protein kinase signaling pathway; Pediatrics; Peripheral blood mononuclear cells; Population studies; Protein arrays; Protein kinase; Proteins; Transcription factors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; vitamin K2; cytokine; atopic dermatitis; mitogen-activated protein kinase signaling pathway; vitamin K2

Vitamin K2 is suggested to have a suppressive effect on the peripheral blood mononuclear cells (PBMCs) of pediatric atopic dermatitis patients. We examined the molecular targets of vitamin K2 to suppress proliferation and cytokine production in T-cell mitogen-activated PBMCs of atopic dermatitis pat...