Genome-wide association studies of brain imaging phenotypes in UK Biobank

• Published in: Nature (London) Vol. 562; no. 7726; pp. 210 - 216
• Main Authors: Elliott, Lloyd T., Sharp, Kevin, Alfaro-Almagro, Fidel, Shi, Sinan, Miller, Karla L., Douaud, Gwenaëlle, Marchini, Jonathan, Smith, Stephen M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2018; Nature Publishing Group
• Subjects: 45/43; 59; 59/57; 631/208/205/2138; 631/208/480; 631/378/2583; Aging; Aging - genetics; Alzheimer's disease; Architecture; Automation; Axonogenesis; Behavior disorders; Biological Specimen Banks; Brain; Brain - anatomy & histology; Brain - diagnostic imaging; Brain - growth & development; Brain - pathology; Brain architecture; Brain research; Chromosomes; Consortia; Datasets as Topic; Developmental plasticity; Epidermal growth factor; Epidermal Growth Factor - genetics; Epidermal growth factors; Extracellular Matrix; Female; Functional anatomy; Gene loci; Genes; Genetic aspects; Genetic polymorphisms; Genome-Wide Association Study; Genomes; Genomics; Growth factors; Heredity; Humanities and Social Sciences; Humans; Imaging; Iron; Iron - metabolism; Iron transport; Lesions; Magnetic permeability; Magnetic susceptibility; Male; Medical imaging; Mental disorders; multidisciplinary; Neurodevelopmental disorders; Neuroimaging; Neurological diseases; Neuronal Plasticity - genetics; NMR; Nuclear magnetic resonance; Phenotype; Phenotypes; Polymorphism, Single Nucleotide - genetics; Putamen - anatomy & histology; Putamen - metabolism; Schizophrenia; Science; Science (multidisciplinary); Signal transduction; Signal Transduction - genetics; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Structure; Structure-function relationships; Substantia alba; United Kingdom; White Matter - anatomy & histology; White Matter - metabolism; White Matter - pathology; United Kingdom; United Kingdom > UK; Genetic Correlation Analysis; Phenome-wide Association Study (PheWAS); Genome-wide Association Studies; GWAS Results; Single Nucleotide Polymorphisms (SNPs)

The genetic architecture of brain structure and function is largely unknown. To investigate this, we carried out genome-wide association studies of 3,144 functional and structural brain imaging phenotypes from UK Biobank (discovery dataset 8,428 subjects). Here we show that many of these phenotypes...