Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase - Tong, Xiaoyong; Khandelwal, Alok R.; Wu, Xiaojuan; Xu, Zaicheng; Yu, Weimin; Chen, Caiyu; Zhao, Wanzhou; Yang, Jian; Qin, Zhexue; Weisbrod, Robert M.; Seta, Francesca; Ago, Tetsuro; et al. (Journal of molecular and cellular cardiology, 2016)
Keywords: Animals; Aorta - metabolism; Aorta - pathology; Apolipoproteins E - genetics; Atherosclerosis; Atherosclerosis - genetics; Atherosclerosis - pathology; Blood Pressure - genetics; Cardiovascular; Cell Movement - genetics; Cell Proliferation - genetics; Gene Expression Regulation; Humans; Inflammation - genetics; Inflammation - pathology; Mice; Mice, Transgenic; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; NADPH Oxidase 4; NADPH Oxidases - biosynthesis; NADPH Oxidases - genetics; Nox4; Reactive Oxygen Species - metabolism; RNA, Small Interfering - genetics; Smooth muscle; Soluble epoxide hydrolase 2; TNFα; TSP1; Smooth muscle; Nox4DN; H2O2; ORO; WD; ICAM1; DBP; MCP1; sEH; Atherosclerosis; ApoE; SDN; EETs; NTg; SBP; VCAM1; SMA; TPPU; SMC; siRNA; LCA; PWV; Soluble epoxide hydrolase 2; ND; ROS; Nox4; MAP; thrombospondin 1; intercellular adhesion molecule 1; systolic blood pressure; smooth muscle human Nox4DN transgenic mice; diastolic blood pressure; Oil Red O; small interference RNA; 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea; left common carotid artery; hydrogen peroxide; soluble epoxide hydrolase 2; H 2O 2; smooth muscle cells; ApoE deficient; Western diet; Nox4 dominant negative form P437H; pulse wave velocity; epoxyeicosatrienoic acids; smooth muscle alpha actin; tumor necrosis factor alpha; monocyte chemoattractant protein 1; non-transgenic littermate mice; reactive oxygen species; vascular cell adhesion molecule 1; mean arterial pressure; normal diet