Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase
Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial. Our goal was to investigate the role of smooth muscle Nox4 in atherosclerosis. Atherosclerosis-prone conditions (disturbed blood flow and Western d...
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| Published in | Journal of molecular and cellular cardiology Vol. 92; pp. 30 - 40 |
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| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.03.2016
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial.
Our goal was to investigate the role of smooth muscle Nox4 in atherosclerosis.
Atherosclerosis-prone conditions (disturbed blood flow and Western diet) increased Nox4 mRNA level in smooth muscle of arteries. To address whether upregulated smooth muscle Nox4 under atherosclerosis-prone conditions was directly involved in the development of atherosclerosis, mice carrying a human Nox4 P437H dominant negative mutation (Nox4DN), specifically in smooth muscle, were generated on a FVB/N ApoE deficient genetic background to counter the effect of increased smooth muscle Nox4. Nox4DN significantly decreased aortic stiffness and atherosclerotic lesions, with no effect on blood pressure. Gene analysis indicated that soluble epoxide hydrolase 2 (sEH) was significantly downregulated in Nox4DN smooth muscle cells (SMC), at both mRNA and protein levels. Downregulation of sEH by siRNA decreased SMC proliferation and migration, and suppressed inflammation and macrophage adhesion to SMC.
Downregulation of smooth muscle Nox4 inhibits atherosclerosis by suppressing sEH, which, at least in part, accounts for inhibition of SMC proliferation, migration and inflammation.
•Atherosclerosis-prone conditions increase Nox4 in smooth muscle of arteries.•Smooth muscle Nox4 plays a detrimental role in the development of atherosclerosis.•Downregulation of smooth muscle Nox4 inhibits atherosclerosis by suppressing sEH.•Nox4 regulates SMC proliferation, migration and inflammation via sEH. |
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| AbstractList | Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial.
Our goal was to investigate the role of smooth muscle Nox4 in atherosclerosis.
Atherosclerosis-prone conditions (disturbed blood flow and Western diet) increased Nox4 mRNA level in smooth muscle of arteries. To address whether upregulated smooth muscle Nox4 under atherosclerosis-prone conditions was directly involved in the development of atherosclerosis, mice carrying a human Nox4 P437H dominant negative mutation (Nox4DN), specifically in smooth muscle, were generated on a FVB/N ApoE deficient genetic background to counter the effect of increased smooth muscle Nox4. Nox4DN significantly decreased aortic stiffness and atherosclerotic lesions, with no effect on blood pressure. Gene analysis indicated that soluble epoxide hydrolase 2 (sEH) was significantly downregulated in Nox4DN smooth muscle cells (SMC), at both mRNA and protein levels. Downregulation of sEH by siRNA decreased SMC proliferation and migration, and suppressed inflammation and macrophage adhesion to SMC.
Downregulation of smooth muscle Nox4 inhibits atherosclerosis by suppressing sEH, which, at least in part, accounts for inhibition of SMC proliferation, migration and inflammation. Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial. Our goal was to investigate the role of smooth muscle Nox4 in atherosclerosis. Atherosclerosis-prone conditions (disturbed blood flow and Western diet) increased Nox4 mRNA level in smooth muscle of arteries. To address whether upregulated smooth muscle Nox4 under atherosclerosis-prone conditions was directly involved in the development of atherosclerosis, mice carrying a human Nox4 P437H dominant negative mutation (Nox4DN), specifically in smooth muscle, were generated on a FVB/N ApoE deficient genetic background to counter the effect of increased smooth muscle Nox4. Nox4DN significantly decreased aortic stiffness and atherosclerotic lesions, with no effect on blood pressure. Gene analysis indicated that soluble epoxide hydrolase 2 (sEH) was significantly downregulated in Nox4DN smooth muscle cells (SMC), at both mRNA and protein levels. Downregulation of sEH by siRNA decreased SMC proliferation and migration, and suppressed inflammation and macrophage adhesion to SMC. Downregulation of smooth muscle Nox4 inhibits atherosclerosis by suppressing sEH, which, at least in part, accounts for inhibition of SMC proliferation, migration and inflammation. •Atherosclerosis-prone conditions increase Nox4 in smooth muscle of arteries.•Smooth muscle Nox4 plays a detrimental role in the development of atherosclerosis.•Downregulation of smooth muscle Nox4 inhibits atherosclerosis by suppressing sEH.•Nox4 regulates SMC proliferation, migration and inflammation via sEH. Abstract Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial. Objective Our goal was to investigate the role of smooth muscle Nox4 in atherosclerosis. Approach and results Atherosclerosis-prone conditions (disturbed blood flow and Western diet) increased Nox4 mRNA level in smooth muscle of arteries. To address whether upregulated smooth muscle Nox4 under atherosclerosis-prone conditions was directly involved in the development of atherosclerosis, mice carrying a human Nox4 P437H dominant negative mutation (Nox4DN), specifically in smooth muscle, were generated on a FVB/N ApoE deficient genetic background to counter the effect of increased smooth muscle Nox4. Nox4DN significantly decreased aortic stiffness and atherosclerotic lesions, with no effect on blood pressure. Gene analysis indicated that soluble epoxide hydrolase 2 (sEH) was significantly downregulated in Nox4DN smooth muscle cells (SMC), at both mRNA and protein levels. Downregulation of sEH by siRNA decreased SMC proliferation and migration, and suppressed inflammation and macrophage adhesion to SMC. Conclusions Downregulation of smooth muscle Nox4 inhibits atherosclerosis by suppressing sEH, which, at least in part, accounts for inhibition of SMC proliferation, migration and inflammation. UNLABELLEDNox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial.OBJECTIVEOur goal was to investigate the role of smooth muscle Nox4 in atherosclerosis.APPROACH AND RESULTSAtherosclerosis-prone conditions (disturbed blood flow and Western diet) increased Nox4 mRNA level in smooth muscle of arteries. To address whether upregulated smooth muscle Nox4 under atherosclerosis-prone conditions was directly involved in the development of atherosclerosis, mice carrying a human Nox4 P437H dominant negative mutation (Nox4DN), specifically in smooth muscle, were generated on a FVB/N ApoE deficient genetic background to counter the effect of increased smooth muscle Nox4. Nox4DN significantly decreased aortic stiffness and atherosclerotic lesions, with no effect on blood pressure. Gene analysis indicated that soluble epoxide hydrolase 2 (sEH) was significantly downregulated in Nox4DN smooth muscle cells (SMC), at both mRNA and protein levels. Downregulation of sEH by siRNA decreased SMC proliferation and migration, and suppressed inflammation and macrophage adhesion to SMC.CONCLUSIONSDownregulation of smooth muscle Nox4 inhibits atherosclerosis by suppressing sEH, which, at least in part, accounts for inhibition of SMC proliferation, migration and inflammation. Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial. |
| Author | Khandelwal, Alok R. Seta, Francesca Yu, Weimin Zhao, Wanzhou Qin, Zhexue Lee, Kin Sing Stephen Sadoshima, Junichi Weisbrod, Robert M. Xu, Zaicheng Zeng, Chunyu Wu, Xiaojuan Yang, Jian Ago, Tetsuro Chen, Caiyu Tong, Xiaoyong Hammock, Bruce D. Cohen, Richard A. |
| AuthorAffiliation | 8 Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA 1 Innovative Drug Research Centre, Chongqing University, Chongqing, 401331, China 6 Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 812-8581, Japan 2 Vascular Biology Section, Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, 02118, USA 4 The Nanjing Han & Zaenker Cancer Institute, OG Pharmaceuticals, Nanjing, 210019, China 5 Department of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China 3 Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, 400042, China 7 Department of Entomology & UCD Comprehensive Cancer Center, University of California-Davis, Davis, CA 95616, USA |
| AuthorAffiliation_xml | – name: 8 Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA – name: 6 Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 812-8581, Japan – name: 7 Department of Entomology & UCD Comprehensive Cancer Center, University of California-Davis, Davis, CA 95616, USA – name: 4 The Nanjing Han & Zaenker Cancer Institute, OG Pharmaceuticals, Nanjing, 210019, China – name: 3 Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, 400042, China – name: 2 Vascular Biology Section, Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, 02118, USA – name: 1 Innovative Drug Research Centre, Chongqing University, Chongqing, 401331, China – name: 5 Department of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China |
| Author_xml | – sequence: 1 givenname: Xiaoyong surname: Tong fullname: Tong, Xiaoyong email: xiaoyongtong@cqu.edu.cn organization: Innovative Drug Research Centre, Chongqing University, Chongqing 401331, China – sequence: 2 givenname: Alok R. surname: Khandelwal fullname: Khandelwal, Alok R. organization: Vascular Biology Section, Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA – sequence: 3 givenname: Xiaojuan surname: Wu fullname: Wu, Xiaojuan organization: Innovative Drug Research Centre, Chongqing University, Chongqing 401331, China – sequence: 4 givenname: Zaicheng surname: Xu fullname: Xu, Zaicheng organization: Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing 400042, China – sequence: 5 givenname: Weimin surname: Yu fullname: Yu, Weimin organization: Innovative Drug Research Centre, Chongqing University, Chongqing 401331, China – sequence: 6 givenname: Caiyu surname: Chen fullname: Chen, Caiyu organization: Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing 400042, China – sequence: 7 givenname: Wanzhou surname: Zhao fullname: Zhao, Wanzhou organization: The Nanjing Han & Zaenker Cancer Institute, OG Pharmaceuticals, Nanjing 210019, China – sequence: 8 givenname: Jian surname: Yang fullname: Yang, Jian organization: Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing 400042, China – sequence: 9 givenname: Zhexue surname: Qin fullname: Qin, Zhexue organization: Department of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China – sequence: 10 givenname: Robert M. surname: Weisbrod fullname: Weisbrod, Robert M. organization: Vascular Biology Section, Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA – sequence: 11 givenname: Francesca surname: Seta fullname: Seta, Francesca organization: Vascular Biology Section, Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA – sequence: 12 givenname: Tetsuro surname: Ago fullname: Ago, Tetsuro organization: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 812-8581, Japan – sequence: 13 givenname: Kin Sing Stephen surname: Lee fullname: Lee, Kin Sing Stephen organization: Department of Entomology & UCD Comprehensive Cancer Center, University of California-Davis, Davis, CA 95616, USA – sequence: 14 givenname: Bruce D. surname: Hammock fullname: Hammock, Bruce D. organization: Department of Entomology & UCD Comprehensive Cancer Center, University of California-Davis, Davis, CA 95616, USA – sequence: 15 givenname: Junichi surname: Sadoshima fullname: Sadoshima, Junichi organization: Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, NJ 07103, USA – sequence: 16 givenname: Richard A. surname: Cohen fullname: Cohen, Richard A. organization: Vascular Biology Section, Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA – sequence: 17 givenname: Chunyu surname: Zeng fullname: Zeng, Chunyu organization: Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing 400042, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26812119$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1152/ajpregu.00606.2011 10.1161/01.ATV.19.8.1960 10.1253/circj.CJ-12-0801 10.1126/science.285.5431.1276 10.1161/CIRCULATIONAHA.113.005015 10.1073/pnas.261710799 10.1182/blood-2010-04-278192 10.1096/fj.08-108829 10.1016/0735-1097(95)00522-6 10.1073/pnas.1002178107 10.1152/ajprenal.00098.2009 10.1097/FJC.0b013e318185fa3c 10.1161/CIRCULATIONAHA.105.581892 10.1161/CIRCULATIONAHA.112.132159 10.1161/01.RES.0000017727.35930.33 10.1152/ajpheart.00799.2009 10.1172/JCI200111927 10.1152/physrev.00047.2009 10.1152/ajpheart.00510.2009 10.1097/MCO.0b013e32832f0d99 10.1016/j.yjmcc.2009.10.022 10.1111/j.1440-1681.2006.04479.x 10.1093/cvr/cvs094 10.1161/ATVBAHA.109.186064 10.1016/j.bmcl.2010.12.042 10.1016/j.freeradbiomed.2015.07.004 10.1161/CIRCRESAHA.110.221242 10.1161/01.RES.87.11.992 10.1161/HYPERTENSIONAHA.113.01744 10.1016/j.yjmcc.2015.11.013 10.1161/01.CIR.0000012917.74432.66 10.1083/jcb.200709049 10.1016/j.etp.2011.09.006 10.1161/ATVBAHA.108.181610 10.1016/j.yjmcc.2007.10.022 10.2147/vhrm.2006.2.1.19 10.3791/1861 10.1152/physrev.00004.2012 10.1152/ajpheart.00543.2009 10.1161/ATVBAHA.107.150250 10.1161/ATVBAHA.110.204099 10.1016/j.freeradbiomed.2009.08.026 |
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| Keywords | TNFα TSP1 Smooth muscle Nox4DN H2O2 ORO WD ICAM1 DBP MCP1 sEH Atherosclerosis ApoE SDN EETs NTg SBP VCAM1 SMA TPPU SMC siRNA LCA PWV Soluble epoxide hydrolase 2 ND ROS Nox4 MAP thrombospondin 1 intercellular adhesion molecule 1 systolic blood pressure smooth muscle human Nox4DN transgenic mice diastolic blood pressure Oil Red O small interference RNA 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea left common carotid artery hydrogen peroxide soluble epoxide hydrolase 2 H 2O 2 smooth muscle cells ApoE deficient Western diet Nox4 dominant negative form P437H pulse wave velocity epoxyeicosatrienoic acids smooth muscle alpha actin tumor necrosis factor alpha monocyte chemoattractant protein 1 non-transgenic littermate mice reactive oxygen species vascular cell adhesion molecule 1 mean arterial pressure normal diet |
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| References | Tong, Ying, Pimentel, Trucillo, Adachi, Cohen (bb0110) 2008; 44 Kuroda, Ago, Matsushima, Zhai, Schneider, Sadoshima (bb0120) 2010; 107 Davis, Thompson, Howard, Morisseau, Hammock, Weiss (bb0190) 2002; 99 Lassègue, Griendling (bb0055) 2010; 30 Tong, Khandelwal, Qin, Wu, Chen, Ago (bb0060) 2015; 89 Wang, Liu, Oyama, Rikitake, Kitamoto, Gitlin (bb0140) 2008; 22 Zhang, Vincelette, Cheng, Mehra, Chen, Anandan (bb0175) 2009; 29 Chiu, Chien (bb0005) 2011; 91 Tong, Hou, Jourd'heuil, Weisbrod, Cohen (bb0105) 2010; 107 Allahverdian, Pannu, Francis (bb0040) 2012; 95 Judkins, Diep, Broughton, Mast, Hooker, Miller (bb0070) 2010; 298 Tong, Schröder (bb0115) 2009; 47 Van Vliet, McGuire, Chafe, Leonard, Joshi, Montani (bb0155) 2006; 33 Anandan, Webb, Chen, Wang, Aavula, Cases (bb0230) 2011; 21 Manhiani, Quigley, Knight, Tasoobshirazi, Moore, Brands (bb0225) 2009; 297 Simon (bb0025) 2012; 76 Craige, Kant, Reif, Chen, Pei, Angoff (bb0090) 2015; 89 Schürmann, Rezende, Kruse, Yasar, Löwe, Fork (bb0080) 2015 Weisbrod, Shiang, Al Sayah, Fry, Bajpai, Reinhart-King (bb0160) 2013; 62 Simpkins, Rudic, Roy, Tsai, Hammock, Imig (bb0215) 2010; 298 Ulu, Davis, Tsai, Kim, Morisseau, Inceoglu (bb0220) 2008; 52 Williams, Cusco, Roddy, Johnstone, Creager (bb0150) 1996; 27 Dansky, Charlton, Sikes, Heath, Simantov, Levin (bb0100) 1999; 19 Sorescu, Weiss, Lassegue, Clempus, Szocs, Sorescu (bb0095) 2002; 105 Chen, Kirber, Xiao, Yang, Keaney (bb0125) 2008; 181 Lane, Smith, Davies (bb0165) 2006; 2 Yu, Xu, Huse, Morisseau, Draper, Newman (bb0180) 2000; 87 Zuccollo, Shi, Mastroianni, Maitland-Toolan, Weisbrod, Zang (bb0145) 2005; 112 Barry-Lane, Patterson, van der Merwe, Hu, Holland, Yeh (bb0065) 2001; 108 Ross (bb0050) 1993; 25 Deng, Theken, Lee (bb0200) 2010; 48 Stamatelopoulos, Karatzi, Sidossis (bb0170) 2009; 12 Ozaki, de Almeida (bb0045) 2013; 65 Gray, Di Marco, Okabe, Szyndralewiez, Heitz, Montezano (bb0085) 2013; 127 Bayat, Xu, Pimentel, Cohen, Jiang (bb0135) 2008; 28 Hopkins (bb0030) 2013; 93 Gray, Di Marco, Okabe, Szyndralewiez, Heitz, Montezano (bb0075) 2013; 127 Sun, Sui, Bradbury, Zeldin, Conte, Liao (bb0195) 2002; 90 Sanborn, Hammock (bb0130) 2012; 53 Revermann, Schloss, Barbosa-Sicard, Mieth, Liebner, Morisseau (bb0210) 2010; 30 Nam, Ni, Rezvan, Suo, Budzyn, Llanos (bb0015) 2009; 297 Allahverdian, Chehroudi, McManus, Abraham, Francis (bb0035) 2014; 129 Nam, Ni, Rezvan, Suo, Budzyn, Llanos (bb0010) 2010 Ni, Qiu, Rezvan, Kwon, Nam, Son (bb0020) 2010; 116 Elmarakby (bb0185) 2012; 302 Node, Huo, Ruan, Yang, Spiecker, Ley (bb0205) 1999; 285 Lassègue (10.1016/j.yjmcc.2016.01.020_bb0055) 2010; 30 Chen (10.1016/j.yjmcc.2016.01.020_bb0125) 2008; 181 Anandan (10.1016/j.yjmcc.2016.01.020_bb0230) 2011; 21 Hopkins (10.1016/j.yjmcc.2016.01.020_bb0030) 2013; 93 Manhiani (10.1016/j.yjmcc.2016.01.020_bb0225) 2009; 297 Ozaki (10.1016/j.yjmcc.2016.01.020_bb0045) 2013; 65 Yu (10.1016/j.yjmcc.2016.01.020_bb0180) 2000; 87 Weisbrod (10.1016/j.yjmcc.2016.01.020_bb0160) 2013; 62 Sorescu (10.1016/j.yjmcc.2016.01.020_bb0095) 2002; 105 Wang (10.1016/j.yjmcc.2016.01.020_bb0140) 2008; 22 Ulu (10.1016/j.yjmcc.2016.01.020_bb0220) 2008; 52 Davis (10.1016/j.yjmcc.2016.01.020_bb0190) 2002; 99 Elmarakby (10.1016/j.yjmcc.2016.01.020_bb0185) 2012; 302 Simon (10.1016/j.yjmcc.2016.01.020_bb0025) 2012; 76 Tong (10.1016/j.yjmcc.2016.01.020_bb0115) 2009; 47 Dansky (10.1016/j.yjmcc.2016.01.020_bb0100) 1999; 19 Tong (10.1016/j.yjmcc.2016.01.020_bb0105) 2010; 107 Gray (10.1016/j.yjmcc.2016.01.020_bb0075) 2013; 127 Gray (10.1016/j.yjmcc.2016.01.020_bb0085) 2013; 127 Tong (10.1016/j.yjmcc.2016.01.020_bb0110) 2008; 44 Lane (10.1016/j.yjmcc.2016.01.020_bb0165) 2006; 2 Sun (10.1016/j.yjmcc.2016.01.020_bb0195) 2002; 90 Bayat (10.1016/j.yjmcc.2016.01.020_bb0135) 2008; 28 Judkins (10.1016/j.yjmcc.2016.01.020_bb0070) 2010; 298 Tong (10.1016/j.yjmcc.2016.01.020_bb0060) 2015; 89 Schürmann (10.1016/j.yjmcc.2016.01.020_bb0080) 2015 Ross (10.1016/j.yjmcc.2016.01.020_bb0050) 1993; 25 Allahverdian (10.1016/j.yjmcc.2016.01.020_bb0035) 2014; 129 Sanborn (10.1016/j.yjmcc.2016.01.020_bb0130) 2012; 53 Barry-Lane (10.1016/j.yjmcc.2016.01.020_bb0065) 2001; 108 Zhang (10.1016/j.yjmcc.2016.01.020_bb0175) 2009; 29 Chiu (10.1016/j.yjmcc.2016.01.020_bb0005) 2011; 91 Nam (10.1016/j.yjmcc.2016.01.020_bb0015) 2009; 297 Craige (10.1016/j.yjmcc.2016.01.020_bb0090) 2015; 89 Stamatelopoulos (10.1016/j.yjmcc.2016.01.020_bb0170) 2009; 12 Van Vliet (10.1016/j.yjmcc.2016.01.020_bb0155) 2006; 33 Allahverdian (10.1016/j.yjmcc.2016.01.020_bb0040) 2012; 95 Zuccollo (10.1016/j.yjmcc.2016.01.020_bb0145) 2005; 112 Nam (10.1016/j.yjmcc.2016.01.020_bb0010) 2010 Kuroda (10.1016/j.yjmcc.2016.01.020_bb0120) 2010; 107 Deng (10.1016/j.yjmcc.2016.01.020_bb0200) 2010; 48 Williams (10.1016/j.yjmcc.2016.01.020_bb0150) 1996; 27 Ni (10.1016/j.yjmcc.2016.01.020_bb0020) 2010; 116 Revermann (10.1016/j.yjmcc.2016.01.020_bb0210) 2010; 30 Simpkins (10.1016/j.yjmcc.2016.01.020_bb0215) 2010; 298 Node (10.1016/j.yjmcc.2016.01.020_bb0205) 1999; 285 |
| References_xml | – volume: 298 start-page: H795 year: 2010 end-page: H806 ident: bb0215 article-title: Soluble epoxide hydrolase inhibition modulates vascular remodeling publication-title: Am. J. Physiol. Heart Circ. Physiol. – volume: 95 start-page: 165 year: 2012 end-page: 172 ident: bb0040 article-title: Contribution of monocyte-derived macrophages and smooth muscle cells to arterial foam cell formation publication-title: Cardiovasc. Res. – volume: 108 start-page: 1513 year: 2001 end-page: 1522 ident: bb0065 article-title: p47phox is required for atherosclerotic lesion progression in ApoE(−/−) mice publication-title: J. Clin. Invest. – volume: 12 start-page: 467 year: 2009 end-page: 473 ident: bb0170 article-title: Noninvasive methods for assessing early markers of atherosclerosis: the role of body composition and nutrition publication-title: Curr. Opin. Clin. Nutr. Metab. Care. – volume: 91 start-page: 327 year: 2011 end-page: 387 ident: bb0005 article-title: Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives publication-title: Physiol. Rev. – volume: 30 start-page: 909 year: 2010 end-page: 914 ident: bb0210 article-title: Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 53 start-page: 7067 year: 2012 end-page: 7075 ident: bb0130 publication-title: NIH Public Access – volume: 90 start-page: 1020 year: 2002 end-page: 1027 ident: bb0195 article-title: Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids publication-title: Circ. Res. – volume: 65 start-page: 297 year: 2013 end-page: 304 ident: bb0045 article-title: Evolution and involution of atherosclerosis and its relationship with vascular reactivity in hypercholesterolemic rabbits publication-title: Exp. Toxicol. Pathol. – volume: 107 start-page: 975 year: 2010 end-page: 983 ident: bb0105 article-title: Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat publication-title: Circ. Res. – volume: 44 start-page: 361 year: 2008 end-page: 369 ident: bb0110 article-title: High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration publication-title: J. Mol. Cell. Cardiol. – volume: 112 start-page: 3001 year: 2005 end-page: 3008 ident: bb0145 article-title: The thromboxane A2 receptor antagonist S18886 prevents enhanced atherogenesis caused by diabetes mellitus publication-title: Circulation – volume: 30 start-page: 653 year: 2010 end-page: 661 ident: bb0055 article-title: NADPH oxidases: functions and pathologies in the vasculature publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 76 start-page: 1811 year: 2012 end-page: 1818 ident: bb0025 article-title: Inflammation and vascular injury publication-title: Circ. J. – volume: 89 start-page: 1 year: 2015 end-page: 7 ident: bb0090 article-title: Endothelial NADPH oxidase 4 protects ApoE publication-title: Free Radic. Biol. Med. – volume: 29 start-page: 1265 year: 2009 end-page: 1270 ident: bb0175 article-title: Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 302 start-page: R321 year: 2012 end-page: R330 ident: bb0185 article-title: Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease publication-title: AJP Regul. Integr. Comp. Physiol. – volume: 127 start-page: 1888 year: 2013 end-page: 1902 ident: bb0075 article-title: Nox1 plays a key role in diabetes accelerated atherosclerosis publication-title: Circulation – volume: 19 start-page: 1960 year: 1999 end-page: 1968 ident: bb0100 article-title: Genetic background determines the extent of atherosclerosis in ApoE-deficient mice publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 105 start-page: 1429 year: 2002 end-page: 1435 ident: bb0095 article-title: Superoxide production and expression of nox family proteins in human atherosclerosis publication-title: Circulation – volume: 181 start-page: 1129 year: 2008 end-page: 1139 ident: bb0125 article-title: Regulation of ROS signal transduction by NADPH oxidase 4 localization publication-title: J. Cell Biol. – volume: 48 start-page: 331 year: 2010 end-page: 341 ident: bb0200 article-title: Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation publication-title: J. Mol. Cell. Cardiol. – volume: 93 start-page: 1317 year: 2013 end-page: 1542 ident: bb0030 article-title: Molecular biology of atherosclerosis publication-title: Physiol. Rev. – volume: 27 start-page: 567 year: 1996 end-page: 574 ident: bb0150 article-title: Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus publication-title: J. Am. Coll. Cardiol. – volume: 62 start-page: 1105 year: 2013 end-page: 1110 ident: bb0160 article-title: Arterial stiffening precedes systolic hypertension in diet-induced obesity publication-title: Hypertension – volume: 2 start-page: 19 year: 2006 end-page: 30 ident: bb0165 article-title: Noninvasive assessment of preclinical atherosclerosis publication-title: Vasc. Health Risk Manag. – volume: 33 start-page: 1007 year: 2006 end-page: 1015 ident: bb0155 article-title: Phenotyping the level of blood pressure by telemetry in mice publication-title: Clin. Exp. Pharmacol. Physiol. – volume: 285 start-page: 1276 year: 1999 end-page: 1279 ident: bb0205 article-title: Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids publication-title: Science – volume: 297 start-page: H1535 year: 2009 end-page: H1543 ident: bb0015 article-title: Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis publication-title: Am. J. Physiol. Heart Circ. Physiol. – volume: 47 start-page: 1578 year: 2009 end-page: 1583 ident: bb0115 article-title: NADPH oxidases are responsible for the failure of nitric oxide to inhibit migration of smooth muscle cells exposed to high glucose publication-title: Free Radic. Biol. Med. – volume: 25 start-page: 2041 year: 1993 end-page: 2043 ident: bb0050 article-title: Atherosclerosis: current understanding of mechanisms and future strategies in therapy publication-title: Transplant. Proc. – volume: 21 start-page: 983 year: 2011 end-page: 988 ident: bb0230 article-title: 1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia publication-title: Bioorg. Med. Chem. Lett. – volume: 89 start-page: 185 year: 2015 end-page: 194 ident: bb0060 article-title: Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia publication-title: J. Mol. Cell. Cardiol. – volume: 22 start-page: 3561 year: 2008 end-page: 3570 ident: bb0140 article-title: Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR publication-title: FASEB J. – volume: 99 start-page: 2222 year: 2002 end-page: 2227 ident: bb0190 article-title: Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation publication-title: Proc. Natl. Acad. Sci. U. S. A. – year: 2010 ident: bb0010 article-title: A model of disturbed flow-induced atherosclerosis in mouse carotid artery by partial ligation and a simple method of RNA isolation from carotid endothelium publication-title: J. Vis. Exp. – volume: 127 start-page: 1888 year: 2013 end-page: 1902 ident: bb0085 article-title: NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis publication-title: Circulation – volume: 297 start-page: F740 year: 2009 end-page: F748 ident: bb0225 article-title: Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension publication-title: Am. J. Physiol. Ren. Physiol. – volume: 298 start-page: H24 year: 2010 end-page: H32 ident: bb0070 article-title: Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE publication-title: Am. J. Physiol. Heart Circ. Physiol. – volume: 107 start-page: 15565 year: 2010 end-page: 15570 ident: bb0120 article-title: NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 87 start-page: 992 year: 2000 end-page: 998 ident: bb0180 article-title: Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids publication-title: Circ. Res. – volume: 129 start-page: 1551 year: 2014 end-page: 1559 ident: bb0035 article-title: Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis publication-title: Circulation – start-page: ehv460 year: 2015 ident: bb0080 article-title: The NADPH oxidase Nox4 has anti-atherosclerotic functions publication-title: Eur. Heart J. – volume: 28 start-page: 127 year: 2008 end-page: 134 ident: bb0135 article-title: Activation of thromboxane receptor upregulates interleukin (IL)-1beta-induced VCAM-1 expression through JNK signaling publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 116 start-page: e66 year: 2010 end-page: e73 ident: bb0020 article-title: Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow publication-title: Blood – volume: 52 start-page: 314 year: 2008 end-page: 323 ident: bb0220 article-title: Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model publication-title: J. Cardiovasc. Pharmacol. – volume: 302 start-page: R321 year: 2012 ident: 10.1016/j.yjmcc.2016.01.020_bb0185 article-title: Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease publication-title: AJP Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00606.2011 – volume: 19 start-page: 1960 year: 1999 ident: 10.1016/j.yjmcc.2016.01.020_bb0100 article-title: Genetic background determines the extent of atherosclerosis in ApoE-deficient mice publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.19.8.1960 – volume: 76 start-page: 1811 year: 2012 ident: 10.1016/j.yjmcc.2016.01.020_bb0025 article-title: Inflammation and vascular injury publication-title: Circ. J. doi: 10.1253/circj.CJ-12-0801 – volume: 285 start-page: 1276 year: 1999 ident: 10.1016/j.yjmcc.2016.01.020_bb0205 article-title: Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids publication-title: Science doi: 10.1126/science.285.5431.1276 – volume: 129 start-page: 1551 year: 2014 ident: 10.1016/j.yjmcc.2016.01.020_bb0035 article-title: Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.113.005015 – volume: 99 start-page: 2222 year: 2002 ident: 10.1016/j.yjmcc.2016.01.020_bb0190 article-title: Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.261710799 – volume: 116 start-page: e66 year: 2010 ident: 10.1016/j.yjmcc.2016.01.020_bb0020 article-title: Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow publication-title: Blood doi: 10.1182/blood-2010-04-278192 – volume: 22 start-page: 3561 year: 2008 ident: 10.1016/j.yjmcc.2016.01.020_bb0140 article-title: Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR−/− mice publication-title: FASEB J. doi: 10.1096/fj.08-108829 – volume: 27 start-page: 567 year: 1996 ident: 10.1016/j.yjmcc.2016.01.020_bb0150 article-title: Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus publication-title: J. Am. Coll. Cardiol. doi: 10.1016/0735-1097(95)00522-6 – volume: 107 start-page: 15565 year: 2010 ident: 10.1016/j.yjmcc.2016.01.020_bb0120 article-title: NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1002178107 – volume: 53 start-page: 7067 year: 2012 ident: 10.1016/j.yjmcc.2016.01.020_bb0130 publication-title: NIH Public Access – volume: 297 start-page: F740 year: 2009 ident: 10.1016/j.yjmcc.2016.01.020_bb0225 article-title: Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension publication-title: Am. J. Physiol. Ren. Physiol. doi: 10.1152/ajprenal.00098.2009 – volume: 52 start-page: 314 year: 2008 ident: 10.1016/j.yjmcc.2016.01.020_bb0220 article-title: Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model publication-title: J. Cardiovasc. Pharmacol. doi: 10.1097/FJC.0b013e318185fa3c – volume: 112 start-page: 3001 year: 2005 ident: 10.1016/j.yjmcc.2016.01.020_bb0145 article-title: The thromboxane A2 receptor antagonist S18886 prevents enhanced atherogenesis caused by diabetes mellitus publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.105.581892 – volume: 127 start-page: 1888 year: 2013 ident: 10.1016/j.yjmcc.2016.01.020_bb0085 article-title: NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.112.132159 – volume: 90 start-page: 1020 year: 2002 ident: 10.1016/j.yjmcc.2016.01.020_bb0195 article-title: Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids publication-title: Circ. Res. doi: 10.1161/01.RES.0000017727.35930.33 – volume: 298 start-page: H24 year: 2010 ident: 10.1016/j.yjmcc.2016.01.020_bb0070 article-title: Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE−/− mice publication-title: Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.00799.2009 – volume: 108 start-page: 1513 year: 2001 ident: 10.1016/j.yjmcc.2016.01.020_bb0065 article-title: p47phox is required for atherosclerotic lesion progression in ApoE(−/−) mice publication-title: J. Clin. Invest. doi: 10.1172/JCI200111927 – volume: 91 start-page: 327 year: 2011 ident: 10.1016/j.yjmcc.2016.01.020_bb0005 article-title: Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives publication-title: Physiol. Rev. doi: 10.1152/physrev.00047.2009 – volume: 297 start-page: H1535 year: 2009 ident: 10.1016/j.yjmcc.2016.01.020_bb0015 article-title: Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis publication-title: Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.00510.2009 – volume: 12 start-page: 467 year: 2009 ident: 10.1016/j.yjmcc.2016.01.020_bb0170 article-title: Noninvasive methods for assessing early markers of atherosclerosis: the role of body composition and nutrition publication-title: Curr. Opin. Clin. Nutr. Metab. Care. doi: 10.1097/MCO.0b013e32832f0d99 – volume: 48 start-page: 331 year: 2010 ident: 10.1016/j.yjmcc.2016.01.020_bb0200 article-title: Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2009.10.022 – volume: 33 start-page: 1007 year: 2006 ident: 10.1016/j.yjmcc.2016.01.020_bb0155 article-title: Phenotyping the level of blood pressure by telemetry in mice publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1111/j.1440-1681.2006.04479.x – volume: 95 start-page: 165 year: 2012 ident: 10.1016/j.yjmcc.2016.01.020_bb0040 article-title: Contribution of monocyte-derived macrophages and smooth muscle cells to arterial foam cell formation publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvs094 – volume: 29 start-page: 1265 year: 2009 ident: 10.1016/j.yjmcc.2016.01.020_bb0175 article-title: Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.109.186064 – volume: 21 start-page: 983 year: 2011 ident: 10.1016/j.yjmcc.2016.01.020_bb0230 article-title: 1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2010.12.042 – volume: 89 start-page: 1 year: 2015 ident: 10.1016/j.yjmcc.2016.01.020_bb0090 article-title: Endothelial NADPH oxidase 4 protects ApoE−/− mice from atherosclerotic lesions publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2015.07.004 – volume: 107 start-page: 975 year: 2010 ident: 10.1016/j.yjmcc.2016.01.020_bb0105 article-title: Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.110.221242 – start-page: ehv460 year: 2015 ident: 10.1016/j.yjmcc.2016.01.020_bb0080 article-title: The NADPH oxidase Nox4 has anti-atherosclerotic functions publication-title: Eur. Heart J. – volume: 87 start-page: 992 year: 2000 ident: 10.1016/j.yjmcc.2016.01.020_bb0180 article-title: Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids publication-title: Circ. Res. doi: 10.1161/01.RES.87.11.992 – volume: 127 start-page: 1888 year: 2013 ident: 10.1016/j.yjmcc.2016.01.020_bb0075 article-title: Nox1 plays a key role in diabetes accelerated atherosclerosis publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.112.132159 – volume: 62 start-page: 1105 year: 2013 ident: 10.1016/j.yjmcc.2016.01.020_bb0160 article-title: Arterial stiffening precedes systolic hypertension in diet-induced obesity publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.113.01744 – volume: 89 start-page: 185 year: 2015 ident: 10.1016/j.yjmcc.2016.01.020_bb0060 article-title: Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2015.11.013 – volume: 105 start-page: 1429 year: 2002 ident: 10.1016/j.yjmcc.2016.01.020_bb0095 article-title: Superoxide production and expression of nox family proteins in human atherosclerosis publication-title: Circulation doi: 10.1161/01.CIR.0000012917.74432.66 – volume: 181 start-page: 1129 year: 2008 ident: 10.1016/j.yjmcc.2016.01.020_bb0125 article-title: Regulation of ROS signal transduction by NADPH oxidase 4 localization publication-title: J. Cell Biol. doi: 10.1083/jcb.200709049 – volume: 65 start-page: 297 year: 2013 ident: 10.1016/j.yjmcc.2016.01.020_bb0045 article-title: Evolution and involution of atherosclerosis and its relationship with vascular reactivity in hypercholesterolemic rabbits publication-title: Exp. Toxicol. Pathol. doi: 10.1016/j.etp.2011.09.006 – volume: 30 start-page: 653 year: 2010 ident: 10.1016/j.yjmcc.2016.01.020_bb0055 article-title: NADPH oxidases: functions and pathologies in the vasculature publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.108.181610 – volume: 44 start-page: 361 year: 2008 ident: 10.1016/j.yjmcc.2016.01.020_bb0110 article-title: High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2007.10.022 – volume: 2 start-page: 19 year: 2006 ident: 10.1016/j.yjmcc.2016.01.020_bb0165 article-title: Noninvasive assessment of preclinical atherosclerosis publication-title: Vasc. Health Risk Manag. doi: 10.2147/vhrm.2006.2.1.19 – volume: 25 start-page: 2041 year: 1993 ident: 10.1016/j.yjmcc.2016.01.020_bb0050 article-title: Atherosclerosis: current understanding of mechanisms and future strategies in therapy publication-title: Transplant. Proc. – year: 2010 ident: 10.1016/j.yjmcc.2016.01.020_bb0010 article-title: A model of disturbed flow-induced atherosclerosis in mouse carotid artery by partial ligation and a simple method of RNA isolation from carotid endothelium publication-title: J. Vis. Exp. doi: 10.3791/1861 – volume: 93 start-page: 1317 year: 2013 ident: 10.1016/j.yjmcc.2016.01.020_bb0030 article-title: Molecular biology of atherosclerosis publication-title: Physiol. Rev. doi: 10.1152/physrev.00004.2012 – volume: 298 start-page: H795 year: 2010 ident: 10.1016/j.yjmcc.2016.01.020_bb0215 article-title: Soluble epoxide hydrolase inhibition modulates vascular remodeling publication-title: Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.00543.2009 – volume: 28 start-page: 127 year: 2008 ident: 10.1016/j.yjmcc.2016.01.020_bb0135 article-title: Activation of thromboxane receptor upregulates interleukin (IL)-1beta-induced VCAM-1 expression through JNK signaling publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.107.150250 – volume: 30 start-page: 909 year: 2010 ident: 10.1016/j.yjmcc.2016.01.020_bb0210 article-title: Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.110.204099 – volume: 47 start-page: 1578 year: 2009 ident: 10.1016/j.yjmcc.2016.01.020_bb0115 article-title: NADPH oxidases are responsible for the failure of nitric oxide to inhibit migration of smooth muscle cells exposed to high glucose publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2009.08.026 |
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| Snippet | Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial.
Our... Abstract Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains... UNLABELLEDNox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains... Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial. |
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| SubjectTerms | Animals Aorta - metabolism Aorta - pathology Apolipoproteins E - genetics Atherosclerosis Atherosclerosis - genetics Atherosclerosis - pathology Blood Pressure - genetics Cardiovascular Cell Movement - genetics Cell Proliferation - genetics Gene Expression Regulation Humans Inflammation - genetics Inflammation - pathology Mice Mice, Transgenic Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology NADPH Oxidase 4 NADPH Oxidases - biosynthesis NADPH Oxidases - genetics Nox4 Reactive Oxygen Species - metabolism RNA, Small Interfering - genetics Smooth muscle Soluble epoxide hydrolase 2 |
| Title | Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase |
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