DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression

• Published in: PloS one Vol. 6; no. 8; p. e23881
• Main Authors: Fuchikami, Manabu, Morinobu, Shigeru, Segawa, Masahiro, Okamoto, Yasumasa, Yamawaki, Shigeto, Ozaki, Norio, Inoue, Takeshi, Kusumi, Ichiro, Koyama, Tsukasa, Tsuchiyama, Kounosuke, Terao, Takeshi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 2011; Public Library of Science (PLoS)
• Subjects: Adult; Analysis; Biology; Biomarkers; Biomarkers - metabolism; Brain; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Case-Control Studies; Classification; Cluster analysis; Clustering; CpG islands; CpG Islands - genetics; Deoxyribonucleic acid; Depressive Disorder, Major - diagnosis; Depressive Disorder, Major - genetics; Diagnosis; Diagnostic systems; DNA; DNA Methylation; Epigenesis, Genetic - genetics; Epigenetic inheritance; Exons - genetics; Female; Genes; Humans; Major depressive disorder; Male; Medical diagnosis; Medical schools; Medicine; Mental depression; Methylation; Middle Aged; Patients; Peripheral blood; Promoter Regions, Genetic - genetics; Psychotropic drugs; Two dimensional analysis; Japan

Major depression, because of its recurring and life-threatening nature, is one of the top 10 diseases for global disease burden. Major depression is still diagnosed on the basis of clinical symptoms in patients. The search for specific biological markers is of great importance to advance the method...