Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia - Fraietta, Joseph A; Lacey, Simon F; Orlando, Elena J; Pruteanu-Malinici, Iulian; Gohil, Mercy; Lundh, Stefan; Boesteanu, Alina C; Wang, Yan; O'Connor, Roddy S; Hwang, Wei-Ting; Pequignot, Edward; Ambrose, David E; et al. (Nature medicine, 2018)
Keywords: Animals; Antigens; Antigens, CD19 - metabolism; Apoptosis; Autoantigens; Biomarkers; Cancer; CD19 antigen; CD27 antigen; CD8 antigen; Cell proliferation; Cell therapy; Chimeric antigen receptors; Chronic lymphocytic leukemia; Cytokines; Exhaustion; Female; Genomics; Glycolysis; Immunological memory; Immunological tolerance; Immunology; Immunotherapy; Immunotherapy, Adoptive; Interleukin 6; Interleukin 6 receptors; Interleukin-6 - metabolism; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell - immunology; Leukemia, Lymphocytic, Chronic, B-Cell - therapy; Lymphatic leukemia; Lymphocytes; Lymphocytes T; Male; Memory cells; Mice; Patients; PD-1 protein; Receptors; Receptors, Chimeric Antigen - metabolism; Remission; Stat3 protein; STAT3 Transcription Factor - metabolism; Transcription, Genetic; Treatment Outcome; Tumors