Galanin Is a Potent In Vivo Modulator of Mesencephalic Serotonergic Neurotransmission

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 27; no. 3; pp. 341 - 356
• Main Authors: Kehr, Jan, Yoshitake, Takashi, Wang, Fu-Hua, Razani, Haleh, Gimenez-Llort, Lydia, Jansson, Anders, Yamaguchi, Masatoshi, Ögren, Sven Ove
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2002; Nature Publishing; Nature Publishing Group
• Subjects: 5-HT1A Receptors; 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology; Analysis of Variance; Animals; Binding sites; Biological and medical sciences; Body Temperature - drug effects; Bradykinin - analogs & derivatives; Bradykinin - pharmacology; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; Dorsal raphe nucleus; Dose-Response Relationship, Drug; Fundamental and applied biological sciences. Psychology; Galanin; Galanin - pharmacology; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Immunohistochemistry; In Situ Hybridization; Locomotor activity; Male; Medical sciences; Medicin och hälsovetenskap; Mesencephalon - cytology; Mesencephalon - drug effects; Mesencephalon - physiology; Microdialysis; Motor Activity - drug effects; Neuropharmacology; Neurosciences; Neurotransmitters. Neurotransmission. Receptors; Peptide Fragments - pharmacology; Pharmacology. Drug treatments; Rats; Rats, Sprague-Dawley; Receptors, Serotonin - drug effects; Receptors, Serotonin - physiology; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin - secretion; Serotoninergic system; Synaptic Transmission - drug effects; Synaptic Transmission - physiology; Tryptophan Hydroxylase - biosynthesis; Tryptophan Hydroxylase - drug effects; Tryptophan Hydroxylase - genetics; Vertebrates: nervous system and sense organs; Sweden; 5-HT1A Receptors; Microdialysis; Galanin; Serotonin; Dorsal raphe nucleus; Hippocampus; Locomotor activity; Serotoninergic transmission; Rat; Galanin receptor; Peptide hormone; Central nervous system; Neuropeptide; 5-HT1A Serotonine receptor; Antagonist; Enzyme; Rodentia; Endogenous substance; Gene expression; Biological activity; Hypothalamic hormone; Locomotion; Vertebrata; Mammalia; Tryptophan 5-monooxygenase; Animal; Intracerebral administration; Raphe nucleus; Oxidoreductases; Brain (vertebrata)

Neurochemical, molecular, immunohistochemical and behavioral methods were used to examine the in vivo effects of the neuropeptide galanin on central 5-HT neurotransmission and on 5-HT1A receptor-mediated responses. Intraventricularly infused galanin caused a long-lasting and dose-dependent reduction...