Dendritic Spines in Depression: What We Learned from Animal Models

• Published in: Journal of neural transplantation & plasticity Vol. 2016; no. 2016; pp. 1 - 26
• Main Authors: An, Shu-Cheng, Chen, Hui-Bin, Xu, Chang, Li, Ming-Xing, Qiao, Hui, Ma, Xin-Ming
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016; John Wiley & Sons, Inc; Wiley
• Subjects: Analysis; Animals; Behavior; Brain; Brain - metabolism; Brain - physiopathology; Dendritic Spines - metabolism; Dendritic Spines - physiology; Depression, Mental; Depressive Disorder - etiology; Depressive Disorder - metabolism; Depressive Disorder - physiopathology; Disease Models, Animal; Female; Humans; Male; Mental depression; Mental disorders; Mice; Morphology; Neuronal Plasticity; Neurons; Protein synthesis; Rats; Restraint, Physical; Review; Stress; Stress response; Stress, Psychological - complications
• ISSN: 2090-5904; 0792-8483; 1687-5443; 1687-5443
• DOI: 10.1155/2016/8056370

Depression, a severe psychiatric disorder, has been studied for decades, but the underlying mechanisms still remain largely unknown. Depression is closely associated with alterations in dendritic spine morphology and spine density. Therefore, understanding dendritic spines is vital for uncovering th...